Abstract
We present the case of a cognitively unimpaired 77-year-old man with elevated, asymmetric, and longitudinally increasing Flortaucipir tau PET despite normal (visually negative) amyloid PET. His atypical tau PET signal persisted and globally increased in a follow-up scan five years later. Across eight years of observations, temporoparietal atrophy was observed consistent with tau PET patterns, but he retained the cognitively unimpaired classification. Altogether, his atypical tau PET signal is not explained by any known risk factors or alternative pathologies, and other imaging findings were not remarkable. He remains enrolled for further observation.
Original language | English (US) |
---|---|
Pages (from-to) | 59-64 |
Number of pages | 6 |
Journal | Journal of Alzheimer's Disease |
Volume | 85 |
Issue number | 1 |
DOIs | |
State | Published - 2022 |
Keywords
- AV-1451
- Alzheimer's disease
- Flortaucipir
- PET imaging
- case reports
- tau proteins
ASJC Scopus subject areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health