Longitudinally Increasing Elevated Asymmetric Flortaucipir Binding in a Cognitively Unimpaired Amyloid-Negative Older Individual

Christopher G. Schwarz, David S. Knopman, Vijay K. Ramanan, Val J. Lowe, Heather J. Wiste, Petrice M. Cogswell, Rene L. Utianski, Matthew L. Senjem, Jeffrey R. Gunter, Prashanthi Vemuri, Ronald C. Petersen, Clifford R. Jack

Research output: Contribution to journalArticlepeer-review

Abstract

We present the case of a cognitively unimpaired 77-year-old man with elevated, asymmetric, and longitudinally increasing Flortaucipir tau PET despite normal (visually negative) amyloid PET. His atypical tau PET signal persisted and globally increased in a follow-up scan five years later. Across eight years of observations, temporoparietal atrophy was observed consistent with tau PET patterns, but he retained the cognitively unimpaired classification. Altogether, his atypical tau PET signal is not explained by any known risk factors or alternative pathologies, and other imaging findings were not remarkable. He remains enrolled for further observation.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalJournal of Alzheimer's Disease
Volume85
Issue number1
DOIs
StatePublished - 2022

Keywords

  • AV-1451
  • Alzheimer's disease
  • Flortaucipir
  • PET imaging
  • case reports
  • tau proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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