Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease

Kejal Kantarci; Stephen D. Weigand; Ronald C. Petersen; Bradley F. Boeve; David S. Knopman; Jeffrey Gunter; Denise Reyes; Maria Shiung; Peter C. O'Brien; Glenn E. Smith; Robert J. Ivnik; Eric G. Tangalos; Clifford R. Jack

doi:10.1016/j.neurobiolaging.2006.06.018

Longitudinal ¹H MRS changes in mild cognitive impairment and Alzheimer's disease

Kejal Kantarci, Stephen D. Weigand, Ronald C. Petersen, Bradley F. Boeve, David S. Knopman, Jeffrey Gunter, Denise Reyes, Maria Shiung, Peter C. O'Brien, Glenn E. Smith, Robert J. Ivnik, Eric G. Tangalos, Clifford R. Jack

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in ¹H MR spectroscopy (¹H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal ¹H MRS metabolite changes in patients with MCI, and AD, and to compare ¹H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in ¹H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that ¹H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.

Original language	English (US)
Pages (from-to)	1330-1339
Number of pages	10
Journal	Neurobiology of aging
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.neurobiolaging.2006.06.018
State	Published - Sep 2007

Keywords

Alzheimer's disease
Choline
H MR spectroscopy
H MRS
Imaging
Longitudinal
Mild cognitive impairment
N-Acetylaspartate
Serial

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2006.06.018

Cite this

Kantarci, K., Weigand, S. D., Petersen, R. C., Boeve, B. F., Knopman, D. S., Gunter, J., Reyes, D., Shiung, M., O'Brien, P. C., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Jack, C. R. (2007). Longitudinal ¹H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging, 28(9), 1330-1339. https://doi.org/10.1016/j.neurobiolaging.2006.06.018

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title = "Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease",

abstract = "Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in 1H MR spectroscopy (1H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal 1H MRS metabolite changes in patients with MCI, and AD, and to compare 1H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in 1H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that 1H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.",

keywords = "Alzheimer's disease, Choline, H MR spectroscopy, H MRS, Imaging, Longitudinal, Mild cognitive impairment, N-Acetylaspartate, Serial",

author = "Kejal Kantarci and Weigand, {Stephen D.} and Petersen, {Ronald C.} and Boeve, {Bradley F.} and Knopman, {David S.} and Jeffrey Gunter and Denise Reyes and Maria Shiung and O'Brien, {Peter C.} and Smith, {Glenn E.} and Ivnik, {Robert J.} and Tangalos, {Eric G.} and Jack, {Clifford R.}",

note = "Funding Information: Supported by NIH Roadmap Multidisciplinary Clinical Research Career Development Award (K12/NICHD)-HD049078, Alzheimer's Association New Investigator Research Grant NIRG-03-4842, NIH/NIA-AG11378, AG06786, and AG16574, and by the Robert H. and Clarince Smith and Abigail Van Buren Alzheimer's Disease Research program.",

year = "2007",

month = sep,

doi = "10.1016/j.neurobiolaging.2006.06.018",

language = "English (US)",

volume = "28",

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journal = "Neurobiology of aging",

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AU - Kantarci, Kejal

AU - Weigand, Stephen D.

AU - Petersen, Ronald C.

AU - Boeve, Bradley F.

AU - Knopman, David S.

AU - Gunter, Jeffrey

AU - Reyes, Denise

AU - Shiung, Maria

AU - O'Brien, Peter C.

AU - Smith, Glenn E.

AU - Ivnik, Robert J.

AU - Tangalos, Eric G.

AU - Jack, Clifford R.

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PY - 2007/9

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N2 - Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in 1H MR spectroscopy (1H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal 1H MRS metabolite changes in patients with MCI, and AD, and to compare 1H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in 1H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that 1H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.

AB - Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in 1H MR spectroscopy (1H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal 1H MRS metabolite changes in patients with MCI, and AD, and to compare 1H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in 1H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that 1H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.

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