Abstract
Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI): AD (n = 152), converters from MCI to probable AD (MCI-C, n = 60), stable MCI (MCI-S, n = 261), and healthy controls (HC, n = 200). Scans were analyzed using multiple methods, including voxel-based morphometry (VBM), regions of interest (ROIs), and automated parcellation, permitting comparison of annual percent change (APC) in neurodegeneration markers. Effect sizes and the sample required to detect 25% reduction in atrophy rates were calculated. The influence of APOE genotype on APC was also evaluated. AD patients and converters from MCI to probable AD demonstrated high atrophy APCs across regions compared with minimal change in healthy controls. Stable MCI subjects showed intermediate atrophy rates. APOE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1401-1418 |
| Number of pages | 18 |
| Journal | Neurobiology of Aging |
| Volume | 31 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2010 |
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Keywords
- Alzheimer's Disease Neuroimaging Initiative (ADNI)
- Apolipoprotein E (APOE) epsilon 4 allele
- Genetic factors
- Hippocampus
- Longitudinal change
- Magnetic resonance imaging (MRI)
- Mild cognitive impairment (MCI)
- Voxel-based morphometry (VBM)
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Aging
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Longitudinal MRI atrophy biomarkers : Relationship to conversion in the ADNI cohort. / Risacher, Shannon L.; Shen, Li; West, John D.; Kim, Sungeun; McDonald, Brenna C.; Beckett, Laurel A.; Harvey, Danielle J.; Jack, Clifford R Jr.; Weiner, Michael W.; Saykin, Andrew J.
In: Neurobiology of Aging, Vol. 31, No. 8, 08.2010, p. 1401-1418.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Longitudinal MRI atrophy biomarkers
T2 - Relationship to conversion in the ADNI cohort
AU - Risacher, Shannon L.
AU - Shen, Li
AU - West, John D.
AU - Kim, Sungeun
AU - McDonald, Brenna C.
AU - Beckett, Laurel A.
AU - Harvey, Danielle J.
AU - Jack, Clifford R Jr.
AU - Weiner, Michael W.
AU - Saykin, Andrew J.
PY - 2010/8
Y1 - 2010/8
N2 - Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI): AD (n = 152), converters from MCI to probable AD (MCI-C, n = 60), stable MCI (MCI-S, n = 261), and healthy controls (HC, n = 200). Scans were analyzed using multiple methods, including voxel-based morphometry (VBM), regions of interest (ROIs), and automated parcellation, permitting comparison of annual percent change (APC) in neurodegeneration markers. Effect sizes and the sample required to detect 25% reduction in atrophy rates were calculated. The influence of APOE genotype on APC was also evaluated. AD patients and converters from MCI to probable AD demonstrated high atrophy APCs across regions compared with minimal change in healthy controls. Stable MCI subjects showed intermediate atrophy rates. APOE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration.
AB - Atrophic changes in early Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI): AD (n = 152), converters from MCI to probable AD (MCI-C, n = 60), stable MCI (MCI-S, n = 261), and healthy controls (HC, n = 200). Scans were analyzed using multiple methods, including voxel-based morphometry (VBM), regions of interest (ROIs), and automated parcellation, permitting comparison of annual percent change (APC) in neurodegeneration markers. Effect sizes and the sample required to detect 25% reduction in atrophy rates were calculated. The influence of APOE genotype on APC was also evaluated. AD patients and converters from MCI to probable AD demonstrated high atrophy APCs across regions compared with minimal change in healthy controls. Stable MCI subjects showed intermediate atrophy rates. APOE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration.
KW - Alzheimer's Disease Neuroimaging Initiative (ADNI)
KW - Apolipoprotein E (APOE) epsilon 4 allele
KW - Genetic factors
KW - Hippocampus
KW - Longitudinal change
KW - Magnetic resonance imaging (MRI)
KW - Mild cognitive impairment (MCI)
KW - Voxel-based morphometry (VBM)
UR - http://www.scopus.com/inward/record.url?scp=77953998854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953998854&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2010.04.029
DO - 10.1016/j.neurobiolaging.2010.04.029
M3 - Article
C2 - 20620664
AN - SCOPUS:77953998854
VL - 31
SP - 1401
EP - 1418
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 8
ER -