Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: Report from the US Pediatric Multiple Sclerosis Network

L. E. Charvet, E. H. O'Donnell, A. L. Belman, T. Chitnis, J. M. Ness, J. Parrish, M. Patterson, M. Rodriguez, E. Waubant, B. Weinstock-Guttman, L. B. Krupp

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: Approximately one-third of those with pediatric-onset multiple sclerosis (MS) experience cognitive impairment. Less is known concerning their change in cognitive functioning over time. Objective: Changes in cognitive function over time were measured in the largest pediatric cohort to date through the US Network of Pediatric MS Centers. Methods: A total of 67 individuals with pediatric MS (n=62) or clinically isolated syndrome (CIS, n=5), ranging from 8-17 years of age (mean age±standard deviation (SD)=14.37±2.02) completed initial and follow-up neuropsychological testing after an average of 1.64±0.63 years apart. The nine tests administered measure general intellect, attention and working memory, verbal memory, visuomotor integration, language, and executive functioning. Results: Rate of impairment (having one-third or more scores in the impaired range) was 37% at baseline and 33% at follow-up. Tests commonly impaired were measures of visuomotor integration, speeded processing, and attention. Most tested did not decline over two years. There was no clear pattern of change on any specific measure. Conclusion: Findings suggest that, over short timeframes, stable or even improved performances on measures of cognitive ability can occur. Pediatric MS may instead prevent expected age-related cognitive gains.

Original languageEnglish (US)
Pages (from-to)1502-1510
Number of pages9
JournalMultiple Sclerosis
Volume20
Issue number11
DOIs
StatePublished - Oct 19 2014

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Multiple Sclerosis
Pediatrics
Aptitude
Short-Term Memory
Cognition
Language

Keywords

  • cognition
  • cognitive impairment
  • longitudinal study
  • multiple sclerosis
  • Pediatric

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Charvet, L. E., O'Donnell, E. H., Belman, A. L., Chitnis, T., Ness, J. M., Parrish, J., ... Krupp, L. B. (2014). Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: Report from the US Pediatric Multiple Sclerosis Network. Multiple Sclerosis, 20(11), 1502-1510. https://doi.org/10.1177/1352458514527862

Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis : Report from the US Pediatric Multiple Sclerosis Network. / Charvet, L. E.; O'Donnell, E. H.; Belman, A. L.; Chitnis, T.; Ness, J. M.; Parrish, J.; Patterson, M.; Rodriguez, M.; Waubant, E.; Weinstock-Guttman, B.; Krupp, L. B.

In: Multiple Sclerosis, Vol. 20, No. 11, 19.10.2014, p. 1502-1510.

Research output: Contribution to journalArticle

Charvet, LE, O'Donnell, EH, Belman, AL, Chitnis, T, Ness, JM, Parrish, J, Patterson, M, Rodriguez, M, Waubant, E, Weinstock-Guttman, B & Krupp, LB 2014, 'Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: Report from the US Pediatric Multiple Sclerosis Network', Multiple Sclerosis, vol. 20, no. 11, pp. 1502-1510. https://doi.org/10.1177/1352458514527862
Charvet, L. E. ; O'Donnell, E. H. ; Belman, A. L. ; Chitnis, T. ; Ness, J. M. ; Parrish, J. ; Patterson, M. ; Rodriguez, M. ; Waubant, E. ; Weinstock-Guttman, B. ; Krupp, L. B. / Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis : Report from the US Pediatric Multiple Sclerosis Network. In: Multiple Sclerosis. 2014 ; Vol. 20, No. 11. pp. 1502-1510.
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