Abstract
Objective To evaluate lung growth in healthy fetuses and those with congenital diaphragmatic hernia (CDH) using two-dimensional (2D) ultrasound. Methods Fetal right lung measurements obtained by 2D ultrasound between 19 and 37 weeks' gestation were evaluated longitudinally in 66 healthy fetuses and 52 fetuses with isolated left-sided CDH. Right lung areas were determined by the 'tracing' and 'longest-diameters' methods and, subsequently, lung area-to-head circumference ratios (LHRs) were calculated. Functions fitted to these size parameters with respect to gestational age were evaluated for three sets of group-wise comparisons: (1) healthy vs CDH fetuses; (2) different degrees of severity of CDH; and (3) CDH fetuses that survived vs those that died by 6 months postpartum. Results There was a significantly slower increase in right lung areas and LHRs with advancing gestational age in CDH fetuses than in healthy individuals (P < 0.05). Compared to those with milder forms of CDH, lung areas and LHRs of fetuses with more severe forms displayed a smaller increase (P < 0.05) and LHRs of fetuses with severe CDH did not increase during pregnancy (P > 0.05). Individuals who died postpartum did not show any increase in LHR (P > 0.05) throughout gestation. Conclusions The right lung area and LHR, calculated using either the longest-diameters or tracing method, display reduced growth rates during gestation in cases of isolated left-sided CDH as compared with healthy fetuses. The growth curve characteristics of fetal lung areas and LHRs may be useful for predicting neonatal mortality.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 566-571 |
| Number of pages | 6 |
| Journal | Ultrasound in Obstetrics and Gynecology |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
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Keywords
- congenital diaphragmatic hernia
- fetal lung
- fetal lung area
- lung-to-head ratio
- prenatal diagnosis
- pulmonary hypoplasia
- ultrasound
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Reproductive Medicine
- Radiology Nuclear Medicine and imaging
- Obstetrics and Gynecology
Cite this
Longitudinal assessment of lung area measurements by two-dimensional ultrasound in fetuses with isolated left-sided congenital diaphragmatic hernia. / Ruano, Rodrigo; Britto, I. S.W.; Sangi-Haghpeykar, H.; Bussamra, L. C.S.; Da Silva, M. M.; Belfort, M. A.; Deter, R. L.; Lee, W.; Tannuri, U.; Zugaib, M.
In: Ultrasound in Obstetrics and Gynecology, Vol. 45, No. 5, 01.01.2015, p. 566-571.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Longitudinal assessment of lung area measurements by two-dimensional ultrasound in fetuses with isolated left-sided congenital diaphragmatic hernia
AU - Ruano, Rodrigo
AU - Britto, I. S.W.
AU - Sangi-Haghpeykar, H.
AU - Bussamra, L. C.S.
AU - Da Silva, M. M.
AU - Belfort, M. A.
AU - Deter, R. L.
AU - Lee, W.
AU - Tannuri, U.
AU - Zugaib, M.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective To evaluate lung growth in healthy fetuses and those with congenital diaphragmatic hernia (CDH) using two-dimensional (2D) ultrasound. Methods Fetal right lung measurements obtained by 2D ultrasound between 19 and 37 weeks' gestation were evaluated longitudinally in 66 healthy fetuses and 52 fetuses with isolated left-sided CDH. Right lung areas were determined by the 'tracing' and 'longest-diameters' methods and, subsequently, lung area-to-head circumference ratios (LHRs) were calculated. Functions fitted to these size parameters with respect to gestational age were evaluated for three sets of group-wise comparisons: (1) healthy vs CDH fetuses; (2) different degrees of severity of CDH; and (3) CDH fetuses that survived vs those that died by 6 months postpartum. Results There was a significantly slower increase in right lung areas and LHRs with advancing gestational age in CDH fetuses than in healthy individuals (P < 0.05). Compared to those with milder forms of CDH, lung areas and LHRs of fetuses with more severe forms displayed a smaller increase (P < 0.05) and LHRs of fetuses with severe CDH did not increase during pregnancy (P > 0.05). Individuals who died postpartum did not show any increase in LHR (P > 0.05) throughout gestation. Conclusions The right lung area and LHR, calculated using either the longest-diameters or tracing method, display reduced growth rates during gestation in cases of isolated left-sided CDH as compared with healthy fetuses. The growth curve characteristics of fetal lung areas and LHRs may be useful for predicting neonatal mortality.
AB - Objective To evaluate lung growth in healthy fetuses and those with congenital diaphragmatic hernia (CDH) using two-dimensional (2D) ultrasound. Methods Fetal right lung measurements obtained by 2D ultrasound between 19 and 37 weeks' gestation were evaluated longitudinally in 66 healthy fetuses and 52 fetuses with isolated left-sided CDH. Right lung areas were determined by the 'tracing' and 'longest-diameters' methods and, subsequently, lung area-to-head circumference ratios (LHRs) were calculated. Functions fitted to these size parameters with respect to gestational age were evaluated for three sets of group-wise comparisons: (1) healthy vs CDH fetuses; (2) different degrees of severity of CDH; and (3) CDH fetuses that survived vs those that died by 6 months postpartum. Results There was a significantly slower increase in right lung areas and LHRs with advancing gestational age in CDH fetuses than in healthy individuals (P < 0.05). Compared to those with milder forms of CDH, lung areas and LHRs of fetuses with more severe forms displayed a smaller increase (P < 0.05) and LHRs of fetuses with severe CDH did not increase during pregnancy (P > 0.05). Individuals who died postpartum did not show any increase in LHR (P > 0.05) throughout gestation. Conclusions The right lung area and LHR, calculated using either the longest-diameters or tracing method, display reduced growth rates during gestation in cases of isolated left-sided CDH as compared with healthy fetuses. The growth curve characteristics of fetal lung areas and LHRs may be useful for predicting neonatal mortality.
KW - congenital diaphragmatic hernia
KW - fetal lung
KW - fetal lung area
KW - lung-to-head ratio
KW - prenatal diagnosis
KW - pulmonary hypoplasia
KW - ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84928594850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928594850&partnerID=8YFLogxK
U2 - 10.1002/uog.13420
DO - 10.1002/uog.13420
M3 - Article
C2 - 24862641
AN - SCOPUS:84928594850
VL - 45
SP - 566
EP - 571
JO - Ultrasound in Obstetrics and Gynecology
JF - Ultrasound in Obstetrics and Gynecology
SN - 0960-7692
IS - 5
ER -