Longevity

Irene Maeve Rea; Giuseppina Candore; Luca Cavallone; Fabiola Olivieri; Maurizio Cardelli; Claudio Franceschi; Giuseppina Colonna-Romano; Domenico Lio; Owen Anthony Ross; Calogero Caruso

Longevity

Irene Maeve Rea, Giuseppina Candore, Luca Cavallone, Fabiola Olivieri, Maurizio Cardelli, Claudio Franceschi, Giuseppina Colonna-Romano, Domenico Lio, Owen Anthony Ross, Calogero Caruso

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

10 Scopus citations

Abstract

Life span is a multifactorial quantitative trait that is affected by genetic and environmental factors. It also contains a stochastic component resulting from the interaction between the individual’s chance of surviving and unpredictable events that occur throughout the life course. Advances in the treatment of fatal diseases and improvements in nutrition and living conditions led to a drastic reduction in death rate at young ages before 1950 and at old ages after 1950 in the developed world. As a result, mean life span has experienced a remarkable increase in developed countries.¹ However, why some people live into their nineties or even become centenarians while others die earlier in life of infection, cancer, or inflammatory diseases such as atheroscelerosis, diabetes, or autoimmune disease remains largely unknown.

Original language	English (US)
Title of host publication	Cytokine Gene Polymorphisms in Multifactorial Conditions
Publisher	CRC Press
Pages	379-394
Number of pages	16
ISBN (Electronic)	9781420005325
ISBN (Print)	0849336198, 9780849336195
State	Published - Jan 1 2006

ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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AU - Rea, Irene Maeve

AU - Candore, Giuseppina

AU - Cavallone, Luca

AU - Olivieri, Fabiola

AU - Cardelli, Maurizio

AU - Franceschi, Claudio

AU - Colonna-Romano, Giuseppina

AU - Lio, Domenico

AU - Ross, Owen Anthony

AU - Caruso, Calogero

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