Abstract
Life span is a multifactorial quantitative trait that is affected by genetic and environmental factors. It also contains a stochastic component resulting from the interaction between the individual’s chance of surviving and unpredictable events that occur throughout the life course. Advances in the treatment of fatal diseases and improvements in nutrition and living conditions led to a drastic reduction in death rate at young ages before 1950 and at old ages after 1950 in the developed world. As a result, mean life span has experienced a remarkable increase in developed countries.1 However, why some people live into their nineties or even become centenarians while others die earlier in life of infection, cancer, or inflammatory diseases such as atheroscelerosis, diabetes, or autoimmune disease remains largely unknown.
| Original language | English (US) |
|---|---|
| Title of host publication | Cytokine Gene Polymorphisms in Multifactorial Conditions |
| Publisher | CRC Press |
| Pages | 379-394 |
| Number of pages | 16 |
| ISBN (Electronic) | 9781420005325 |
| ISBN (Print) | 0849336198, 9780849336195 |
| State | Published - Jan 1 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Longevity. / Rea, Irene Maeve; Candore, Giuseppina; Cavallone, Luca; Olivieri, Fabiola; Cardelli, Maurizio; Franceschi, Claudio; Colonna-Romano, Giuseppina; Lio, Domenico; Ross, Owen A; Caruso, Calogero.
Cytokine Gene Polymorphisms in Multifactorial Conditions. CRC Press, 2006. p. 379-394.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Longevity
AU - Rea, Irene Maeve
AU - Candore, Giuseppina
AU - Cavallone, Luca
AU - Olivieri, Fabiola
AU - Cardelli, Maurizio
AU - Franceschi, Claudio
AU - Colonna-Romano, Giuseppina
AU - Lio, Domenico
AU - Ross, Owen A
AU - Caruso, Calogero
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Life span is a multifactorial quantitative trait that is affected by genetic and environmental factors. It also contains a stochastic component resulting from the interaction between the individual’s chance of surviving and unpredictable events that occur throughout the life course. Advances in the treatment of fatal diseases and improvements in nutrition and living conditions led to a drastic reduction in death rate at young ages before 1950 and at old ages after 1950 in the developed world. As a result, mean life span has experienced a remarkable increase in developed countries.1 However, why some people live into their nineties or even become centenarians while others die earlier in life of infection, cancer, or inflammatory diseases such as atheroscelerosis, diabetes, or autoimmune disease remains largely unknown.
AB - Life span is a multifactorial quantitative trait that is affected by genetic and environmental factors. It also contains a stochastic component resulting from the interaction between the individual’s chance of surviving and unpredictable events that occur throughout the life course. Advances in the treatment of fatal diseases and improvements in nutrition and living conditions led to a drastic reduction in death rate at young ages before 1950 and at old ages after 1950 in the developed world. As a result, mean life span has experienced a remarkable increase in developed countries.1 However, why some people live into their nineties or even become centenarians while others die earlier in life of infection, cancer, or inflammatory diseases such as atheroscelerosis, diabetes, or autoimmune disease remains largely unknown.
UR - http://www.scopus.com/inward/record.url?scp=77954659338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954659338&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:77954659338
SN - 0849336198
SN - 9780849336195
SP - 379
EP - 394
BT - Cytokine Gene Polymorphisms in Multifactorial Conditions
PB - CRC Press
ER -