TY - JOUR
T1 - Long-term Visual Outcome and Complications Associated with Pars Planitis
AU - Malinowski, Susan M.
AU - Pulido, Jose S.
AU - Folk, James C.
N1 - Funding Information:
Originally received: October 5, 1992. Revision accepted: December 28, I 992. From the Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City. Dr. Pulido is currently affiliated with The Eye Institute, Medical College of Wisconsin, Milwaukee, Wisconsin. Presented at the American Academy of Ophthalmology Annual Meeting, Dallas, November I 992. Supported in part by funds from Research to Prevent Blindness, Inc, New York, New York, and The Retina Research Fund, University of Iowa, and a generous grant from Mrs. Margaret Logan.
PY - 1993
Y1 - 1993
N2 - Purpose: To identify the ocular complications and to statistically evaluate the possible association of pars planitis with multiple sclerosis (MS) in a homogeneous population of pars planitis patients. Methods: The authors reexamined 36 patients and reviewed the records of an additional 18 patients (total: 54 patients, 108 eyes) with idiopathic pars planitis. Results: The initial mean visual acuity of 20/46 (IogMAR: 0.36 ± 0.50) was not statistically different from the final mean visual acuity of 20/44 (IogMAR: 0.34 ± 0.45; P = 0.73), after a mean follow-up of 89.2 months. Complications included neovascularization with or without associated vitreous hemorrhage (7 eyes, 6.5%), moderate to severe cellophane retinopathy (7 eyes, 6.5%), chronic cystoid macular edema (CME) (9 eyes, 8.3%), visually significant cataracts (16 eyes, 14.8%), and retinal detachment (9 eyes, 8.3%). Significant lens opacification was associated with a greater risk of retinal detachment (P = 0.004). In four patients (7.4%), optic neuritis developed, and in an additional eight patients (14.8%) MS developed. Kaplan-Meier analysis of these data showed a 16.2% ± 6.2% risk of MS solely developing in patients, and a 20.4% ± 6.7% risk of either MS or optic neuritis developing, after 5 years of disease. The presence of periphlebitis at the time of pars planitis diagnosis increased the rate of development of these conditions (P = 0.002). Six patients (11.1 %) had a family history positive for MS in a first-degree relative. Conclusions: This study demonstrates the overall favorable visual prognosis in patients with pars planitis. Patients with significant cataract formation appear to be at greater risk for retinal detachment. Periphlebitis at the time of diagnosis of pars planitis increases the risk of development of optic neuritis or MS. The strong association demonstrated between pars planitis and MS in this study further supports a link between the two disease states.
AB - Purpose: To identify the ocular complications and to statistically evaluate the possible association of pars planitis with multiple sclerosis (MS) in a homogeneous population of pars planitis patients. Methods: The authors reexamined 36 patients and reviewed the records of an additional 18 patients (total: 54 patients, 108 eyes) with idiopathic pars planitis. Results: The initial mean visual acuity of 20/46 (IogMAR: 0.36 ± 0.50) was not statistically different from the final mean visual acuity of 20/44 (IogMAR: 0.34 ± 0.45; P = 0.73), after a mean follow-up of 89.2 months. Complications included neovascularization with or without associated vitreous hemorrhage (7 eyes, 6.5%), moderate to severe cellophane retinopathy (7 eyes, 6.5%), chronic cystoid macular edema (CME) (9 eyes, 8.3%), visually significant cataracts (16 eyes, 14.8%), and retinal detachment (9 eyes, 8.3%). Significant lens opacification was associated with a greater risk of retinal detachment (P = 0.004). In four patients (7.4%), optic neuritis developed, and in an additional eight patients (14.8%) MS developed. Kaplan-Meier analysis of these data showed a 16.2% ± 6.2% risk of MS solely developing in patients, and a 20.4% ± 6.7% risk of either MS or optic neuritis developing, after 5 years of disease. The presence of periphlebitis at the time of pars planitis diagnosis increased the rate of development of these conditions (P = 0.002). Six patients (11.1 %) had a family history positive for MS in a first-degree relative. Conclusions: This study demonstrates the overall favorable visual prognosis in patients with pars planitis. Patients with significant cataract formation appear to be at greater risk for retinal detachment. Periphlebitis at the time of diagnosis of pars planitis increases the risk of development of optic neuritis or MS. The strong association demonstrated between pars planitis and MS in this study further supports a link between the two disease states.
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U2 - 10.1016/S0161-6420(93)31567-8
DO - 10.1016/S0161-6420(93)31567-8
M3 - Article
C2 - 8510893
AN - SCOPUS:0027273240
SN - 0161-6420
VL - 100
SP - 818
EP - 825
JO - Ophthalmology
JF - Ophthalmology
IS - 6
ER -