LONG-TERM USE OF THIAZIDE DIURETICS AND RISK OF HIP FRACTURE

WayneA Ray, Winanne Downey, MarieR Griffin, L. Joseph Melton

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

To assess whether long-term thiazide use is associated with a decreased risk of hip fracture, a nested case-control study was done in the Canadian province of Saskatchewan between 1984 and 1985 among residents who were 65 years of age or older and who were not receiving other drugs thought to affect bone mass. There were 905 hip fractures identified from hospital discharge records and 5137 population controls matched for age, sex, and calendar year. Drug use was ascertained from computerised pharmacy records. Risk of hip fracture decreased significantly with increasing duration of current thiazide use: relative risk (95% confidence interval) of 1·2 (0·9-1·5) for less than 2 years use, 0·8 (0·7-1·0) for use of 2-5 years, and 0·5 (0·3-0·7) for 6 or more years. In contrast, there was no such trend for use of other antihypertensive-diuretic drugs (relative risk 0·9 [0·6-1.3] for use of 6 or more years). This protective effect was not altered by age, sex, nursing home residence, previous hospital admission, or use of other antihypertensive-diuretic drugs or psychotropic drugs. Medical record review for a sample of 235 cases suggested this finding was not due to confounding by body mass, ambulatory status, functional status, or dementia. These results support the hypothesis that thiazides protect against osteoporosis in elderly people.

Original languageEnglish (US)
Pages (from-to)687-690
Number of pages4
JournalThe Lancet
Volume333
Issue number8640
DOIs
StatePublished - Apr 1 1989

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Sodium Chloride Symporter Inhibitors
Hip Fractures
Thiazides
Diuretics
Antihypertensive Agents
Saskatchewan
Population Control
Hospital Records
Psychotropic Drugs
Nursing Homes
Pharmaceutical Preparations
Osteoporosis
Medical Records
Dementia
Case-Control Studies
Confidence Intervals
Bone and Bones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ray, W., Downey, W., Griffin, M., & Joseph Melton, L. (1989). LONG-TERM USE OF THIAZIDE DIURETICS AND RISK OF HIP FRACTURE. The Lancet, 333(8640), 687-690. https://doi.org/10.1016/S0140-6736(89)92205-8

LONG-TERM USE OF THIAZIDE DIURETICS AND RISK OF HIP FRACTURE. / Ray, WayneA; Downey, Winanne; Griffin, MarieR; Joseph Melton, L.

In: The Lancet, Vol. 333, No. 8640, 01.04.1989, p. 687-690.

Research output: Contribution to journalArticle

Ray, W, Downey, W, Griffin, M & Joseph Melton, L 1989, 'LONG-TERM USE OF THIAZIDE DIURETICS AND RISK OF HIP FRACTURE', The Lancet, vol. 333, no. 8640, pp. 687-690. https://doi.org/10.1016/S0140-6736(89)92205-8
Ray W, Downey W, Griffin M, Joseph Melton L. LONG-TERM USE OF THIAZIDE DIURETICS AND RISK OF HIP FRACTURE. The Lancet. 1989 Apr 1;333(8640):687-690. https://doi.org/10.1016/S0140-6736(89)92205-8
Ray, WayneA ; Downey, Winanne ; Griffin, MarieR ; Joseph Melton, L. / LONG-TERM USE OF THIAZIDE DIURETICS AND RISK OF HIP FRACTURE. In: The Lancet. 1989 ; Vol. 333, No. 8640. pp. 687-690.
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