TY - JOUR
T1 - Long-term trends in thyroid carcinoma
T2 - A population-based study in Olmsted County, Minnesota, 1935-1999
AU - Burke, James P.
AU - Hay, Ian D.
AU - Dignan, Fiona
AU - Goellner, John R.
AU - Achenbach, Sara J.
AU - Oberg, Ann L.
AU - Melton, L. Joseph
N1 - Funding Information:
This study was supported in part by research grant AR30582 from the National Institutes of Health, Public Health Service .
PY - 2005/6
Y1 - 2005/6
N2 - OBJECTIVE: To determine whether there was a significant increase in the incidence of thyroid carcinoma in Olmsted County, Minnesota, that may be attributed to the widespread use of therapeutic head and neck irradiation between 1920 and the 1950s or to exposure to atomic fallout at the Nevada Test Site in the 1960s. METHODS: Rochester Epidemiology Project resources were used to identify potential cases of thyroid carcinoma among residents of Olmsted County between 1935 and 1984. We extended this earlier study through 1999. RESULTS: During the study period, thyroid carcinoma was newly diagnosed in 263 residents. In women, the age-adjusted incidence increased from 2.7 per 100,000 person-years (p-y) in 1935-1949 to 9.2 per 100,000 p-y in 1990-1999 (P=.001); in men, the rate increased from 0.8 to 5.0 per 100,000 p-y (P=.007). However, most of the increase occurred before 1965 and remained relatively stable thereafter. Similar trends were observed for papillary carcinoma alone. CONCLUSION: Although the incidence of thyroid carcinoma increased significantly between 1935 and 1964, no significant increases have been seen since 1965, suggesting that neither atmospheric atomic fallout from the Nevada Test Site nor use of ionizing radiation to treat conditions of the head and neck significantly affected the incidence of thyroid carcinoma in Olmsted County.
AB - OBJECTIVE: To determine whether there was a significant increase in the incidence of thyroid carcinoma in Olmsted County, Minnesota, that may be attributed to the widespread use of therapeutic head and neck irradiation between 1920 and the 1950s or to exposure to atomic fallout at the Nevada Test Site in the 1960s. METHODS: Rochester Epidemiology Project resources were used to identify potential cases of thyroid carcinoma among residents of Olmsted County between 1935 and 1984. We extended this earlier study through 1999. RESULTS: During the study period, thyroid carcinoma was newly diagnosed in 263 residents. In women, the age-adjusted incidence increased from 2.7 per 100,000 person-years (p-y) in 1935-1949 to 9.2 per 100,000 p-y in 1990-1999 (P=.001); in men, the rate increased from 0.8 to 5.0 per 100,000 p-y (P=.007). However, most of the increase occurred before 1965 and remained relatively stable thereafter. Similar trends were observed for papillary carcinoma alone. CONCLUSION: Although the incidence of thyroid carcinoma increased significantly between 1935 and 1964, no significant increases have been seen since 1965, suggesting that neither atmospheric atomic fallout from the Nevada Test Site nor use of ionizing radiation to treat conditions of the head and neck significantly affected the incidence of thyroid carcinoma in Olmsted County.
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U2 - 10.1016/s0025-6196(11)61529-2
DO - 10.1016/s0025-6196(11)61529-2
M3 - Article
C2 - 15948298
AN - SCOPUS:20044376123
SN - 0025-6196
VL - 80
SP - 753
EP - 758
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 6
ER -