Long-term survival of patients with Wegener's granulomatosis from the American College of Rheumatology Wegener's granulomatosis classification criteria cohort

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Abstract

Objective: To determine survivorship in Wegener's granulomatosis (WG) in a well-defined multicenter cohort. Methods: Follow-up was obtained for 77 of the 85 patients enrolled in the 1990 American College of Rheumatology vasculitis classification study. Results: There were 28 deaths (10 females and 18 males) among the 77 patients available for follow-up. Standardized mortality ratios (SMR) were calculated with mortality data from the general population and from this group of patients with WG (an SMR of 1 indicates that expected and observed survival are identical). Overall survivorship among patients with WG was substantially reduced in this cohort (SMR = 4.685 ± 0.65; for females SMR = 6.814 ± 1.571; for males SMR = 3.998 ± 0.69). Conclusion: The life expectancy of patients with WG is reduced compared with the general population.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalAmerican Journal of Medicine
Volume101
Issue number2
DOIs
StatePublished - 1996

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Granulomatosis with Polyangiitis
Survival
Mortality
Survival Rate
Vasculitis
Life Expectancy
Population Groups
Population

ASJC Scopus subject areas

  • Nursing(all)

Cite this

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title = "Long-term survival of patients with Wegener's granulomatosis from the American College of Rheumatology Wegener's granulomatosis classification criteria cohort",
abstract = "Objective: To determine survivorship in Wegener's granulomatosis (WG) in a well-defined multicenter cohort. Methods: Follow-up was obtained for 77 of the 85 patients enrolled in the 1990 American College of Rheumatology vasculitis classification study. Results: There were 28 deaths (10 females and 18 males) among the 77 patients available for follow-up. Standardized mortality ratios (SMR) were calculated with mortality data from the general population and from this group of patients with WG (an SMR of 1 indicates that expected and observed survival are identical). Overall survivorship among patients with WG was substantially reduced in this cohort (SMR = 4.685 ± 0.65; for females SMR = 6.814 ± 1.571; for males SMR = 3.998 ± 0.69). Conclusion: The life expectancy of patients with WG is reduced compared with the general population.",
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N2 - Objective: To determine survivorship in Wegener's granulomatosis (WG) in a well-defined multicenter cohort. Methods: Follow-up was obtained for 77 of the 85 patients enrolled in the 1990 American College of Rheumatology vasculitis classification study. Results: There were 28 deaths (10 females and 18 males) among the 77 patients available for follow-up. Standardized mortality ratios (SMR) were calculated with mortality data from the general population and from this group of patients with WG (an SMR of 1 indicates that expected and observed survival are identical). Overall survivorship among patients with WG was substantially reduced in this cohort (SMR = 4.685 ± 0.65; for females SMR = 6.814 ± 1.571; for males SMR = 3.998 ± 0.69). Conclusion: The life expectancy of patients with WG is reduced compared with the general population.

AB - Objective: To determine survivorship in Wegener's granulomatosis (WG) in a well-defined multicenter cohort. Methods: Follow-up was obtained for 77 of the 85 patients enrolled in the 1990 American College of Rheumatology vasculitis classification study. Results: There were 28 deaths (10 females and 18 males) among the 77 patients available for follow-up. Standardized mortality ratios (SMR) were calculated with mortality data from the general population and from this group of patients with WG (an SMR of 1 indicates that expected and observed survival are identical). Overall survivorship among patients with WG was substantially reduced in this cohort (SMR = 4.685 ± 0.65; for females SMR = 6.814 ± 1.571; for males SMR = 3.998 ± 0.69). Conclusion: The life expectancy of patients with WG is reduced compared with the general population.

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