Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder: Results from a population-based study

William J. Barbaresi, Slavica K Katusic, Robert C. Colligan, Amy L. Weaver, Cynthia L. Leibson, Steven J. Jacobsen

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

The purpose of this study was to offer detailed information about stimulant medication treatment provided throughout childhood to 379 children with research-identified attention-deficit hyperactivity disorder (ADHD) in the 1976-1982 Rochester, MN, birth cohort. Subjects were retrospectively followed from birth until a mean of 17.2 years of age. The complete medical record of each subject was reviewed. The history and results of each episode of stimulant treatment were compared by gender, DSM-IV subtype of ADHD, and type of stimulant medication. Overall, 77.8% of subjects were treated with stimulants. Boys were 1.8 times more likely than girls to be treated. The median age at initiation (9.8 years), median duration of treatment (33.8 months), and likelihood of developing at least one side effect (22.3%) were not significantly different by gender. Overall, 73.1% of episodes of stimulant treatment were associated with a favorable response. The likelihood of a favorable response was comparable for boys and girls. Treatment was initiated earlier for children with either ADHD combined type or ADHD hyperactive-impulsive type than for children with ADHD predominantly inattentive type and duration of treatment was longer for ADHD combined type. There was no association between DSM-IV subtype and likelihood of a favorable response or of side effects. Dextroamphetamine and methylphenidate were equally likely to be associated with a favorable response, but dextroamphetamine was more likely to be associated with side effects. These results demonstrate that the effectiveness of stimulant medication treatment of ADHD provided throughout childhood is comparable to the efficacy of stimulant treatment demonstrated in clinical trials.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Developmental and Behavioral Pediatrics
Volume27
Issue number1
DOIs
StatePublished - Feb 2006

Fingerprint

Attention Deficit Disorder with Hyperactivity
Population
Dextroamphetamine
Diagnostic and Statistical Manual of Mental Disorders
Therapeutics
Parturition
Methylphenidate
Medical Records
History
Clinical Trials
Research

Keywords

  • Attention-deficit hyperactivity disorder
  • Effectiveness
  • Stimulant treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Behavioral Neuroscience
  • Psychology(all)
  • Developmental and Educational Psychology

Cite this

Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder : Results from a population-based study. / Barbaresi, William J.; Katusic, Slavica K; Colligan, Robert C.; Weaver, Amy L.; Leibson, Cynthia L.; Jacobsen, Steven J.

In: Journal of Developmental and Behavioral Pediatrics, Vol. 27, No. 1, 02.2006, p. 1-10.

Research output: Contribution to journalArticle

Barbaresi, William J. ; Katusic, Slavica K ; Colligan, Robert C. ; Weaver, Amy L. ; Leibson, Cynthia L. ; Jacobsen, Steven J. / Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder : Results from a population-based study. In: Journal of Developmental and Behavioral Pediatrics. 2006 ; Vol. 27, No. 1. pp. 1-10.
@article{6690d8b126a54893a06550b22c5437ac,
title = "Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder: Results from a population-based study",
abstract = "The purpose of this study was to offer detailed information about stimulant medication treatment provided throughout childhood to 379 children with research-identified attention-deficit hyperactivity disorder (ADHD) in the 1976-1982 Rochester, MN, birth cohort. Subjects were retrospectively followed from birth until a mean of 17.2 years of age. The complete medical record of each subject was reviewed. The history and results of each episode of stimulant treatment were compared by gender, DSM-IV subtype of ADHD, and type of stimulant medication. Overall, 77.8{\%} of subjects were treated with stimulants. Boys were 1.8 times more likely than girls to be treated. The median age at initiation (9.8 years), median duration of treatment (33.8 months), and likelihood of developing at least one side effect (22.3{\%}) were not significantly different by gender. Overall, 73.1{\%} of episodes of stimulant treatment were associated with a favorable response. The likelihood of a favorable response was comparable for boys and girls. Treatment was initiated earlier for children with either ADHD combined type or ADHD hyperactive-impulsive type than for children with ADHD predominantly inattentive type and duration of treatment was longer for ADHD combined type. There was no association between DSM-IV subtype and likelihood of a favorable response or of side effects. Dextroamphetamine and methylphenidate were equally likely to be associated with a favorable response, but dextroamphetamine was more likely to be associated with side effects. These results demonstrate that the effectiveness of stimulant medication treatment of ADHD provided throughout childhood is comparable to the efficacy of stimulant treatment demonstrated in clinical trials.",
keywords = "Attention-deficit hyperactivity disorder, Effectiveness, Stimulant treatment",
author = "Barbaresi, {William J.} and Katusic, {Slavica K} and Colligan, {Robert C.} and Weaver, {Amy L.} and Leibson, {Cynthia L.} and Jacobsen, {Steven J.}",
year = "2006",
month = "2",
doi = "10.1097/00004703-200602000-00001",
language = "English (US)",
volume = "27",
pages = "1--10",
journal = "Journal of Developmental and Behavioral Pediatrics",
issn = "0196-206X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder

T2 - Results from a population-based study

AU - Barbaresi, William J.

AU - Katusic, Slavica K

AU - Colligan, Robert C.

AU - Weaver, Amy L.

AU - Leibson, Cynthia L.

AU - Jacobsen, Steven J.

PY - 2006/2

Y1 - 2006/2

N2 - The purpose of this study was to offer detailed information about stimulant medication treatment provided throughout childhood to 379 children with research-identified attention-deficit hyperactivity disorder (ADHD) in the 1976-1982 Rochester, MN, birth cohort. Subjects were retrospectively followed from birth until a mean of 17.2 years of age. The complete medical record of each subject was reviewed. The history and results of each episode of stimulant treatment were compared by gender, DSM-IV subtype of ADHD, and type of stimulant medication. Overall, 77.8% of subjects were treated with stimulants. Boys were 1.8 times more likely than girls to be treated. The median age at initiation (9.8 years), median duration of treatment (33.8 months), and likelihood of developing at least one side effect (22.3%) were not significantly different by gender. Overall, 73.1% of episodes of stimulant treatment were associated with a favorable response. The likelihood of a favorable response was comparable for boys and girls. Treatment was initiated earlier for children with either ADHD combined type or ADHD hyperactive-impulsive type than for children with ADHD predominantly inattentive type and duration of treatment was longer for ADHD combined type. There was no association between DSM-IV subtype and likelihood of a favorable response or of side effects. Dextroamphetamine and methylphenidate were equally likely to be associated with a favorable response, but dextroamphetamine was more likely to be associated with side effects. These results demonstrate that the effectiveness of stimulant medication treatment of ADHD provided throughout childhood is comparable to the efficacy of stimulant treatment demonstrated in clinical trials.

AB - The purpose of this study was to offer detailed information about stimulant medication treatment provided throughout childhood to 379 children with research-identified attention-deficit hyperactivity disorder (ADHD) in the 1976-1982 Rochester, MN, birth cohort. Subjects were retrospectively followed from birth until a mean of 17.2 years of age. The complete medical record of each subject was reviewed. The history and results of each episode of stimulant treatment were compared by gender, DSM-IV subtype of ADHD, and type of stimulant medication. Overall, 77.8% of subjects were treated with stimulants. Boys were 1.8 times more likely than girls to be treated. The median age at initiation (9.8 years), median duration of treatment (33.8 months), and likelihood of developing at least one side effect (22.3%) were not significantly different by gender. Overall, 73.1% of episodes of stimulant treatment were associated with a favorable response. The likelihood of a favorable response was comparable for boys and girls. Treatment was initiated earlier for children with either ADHD combined type or ADHD hyperactive-impulsive type than for children with ADHD predominantly inattentive type and duration of treatment was longer for ADHD combined type. There was no association between DSM-IV subtype and likelihood of a favorable response or of side effects. Dextroamphetamine and methylphenidate were equally likely to be associated with a favorable response, but dextroamphetamine was more likely to be associated with side effects. These results demonstrate that the effectiveness of stimulant medication treatment of ADHD provided throughout childhood is comparable to the efficacy of stimulant treatment demonstrated in clinical trials.

KW - Attention-deficit hyperactivity disorder

KW - Effectiveness

KW - Stimulant treatment

UR - http://www.scopus.com/inward/record.url?scp=33746635186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746635186&partnerID=8YFLogxK

U2 - 10.1097/00004703-200602000-00001

DO - 10.1097/00004703-200602000-00001

M3 - Article

C2 - 16511362

AN - SCOPUS:33746635186

VL - 27

SP - 1

EP - 10

JO - Journal of Developmental and Behavioral Pediatrics

JF - Journal of Developmental and Behavioral Pediatrics

SN - 0196-206X

IS - 1

ER -