Long-term outcomes in primary spinal osteochondroma: A multicenter study of 27 patients

Daniel M. Sciubba, Mohamed Macki, Mohamad Bydon, Niccole M. Germscheid, Jean Paul Wolinsky, Stefano Boriani, Chetan Bettegowda, Dean Chou, Alessandro Luzzati, Jeremy J. Reynolds, Zsolt Szövérfi, Patti Zadnik, Laurence D. Rhines, Ziya L. Gokaslan, Charles G. Fisher, Peter Paul Varga

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECT: Clinical outcomes in patients with primary spinal osteochondromas are limited to small series and sporadic case reports. The authors present data on the first long-term investigation of spinal osteochondroma cases. METHODS: An international, multicenter ambispective study on primary spinal osteochondroma was performed. Patients were included if they were diagnosed with an osteochondroma of the spine and received surgical treatment between October 1996 and June 2012 with at least 1 follow-up. Perioperative prognostic variables, including patient age, tumor size, spinal level, and resection, were analyzed in reference to long-term local recurrence and survival. Tumor resections were compared using Enneking appropriate (EA) or Enneking inappropriate surgical margins. RESULTS: Osteochondromas were diagnosed in 27 patients at an average age of 37 years. Twenty-two lesions were found in the mobile spine (cervical, thoracic, or lumbar) and 5 in the fixed spine (sacrum). Twenty-three cases (88%) were benign tumors (Enneking tumor Stages 1-3), whereas 3 (12%) exhibited malignant changes (Enneking tumor Stages IA-IIB). Sixteen patients (62%) underwent en bloc treatment - that is, wide or marginal resection - and 10 (38%) underwent intralesional resection. Twenty-four operations (92%) followed EA margins. No one received adjuvant therapy. Two patients (8%) experienced recurrences: one in the fixed spine and one in the mobile spine. Both recurrences occurred in latent Stage 1 tumors following en bloc resection. No osteochondroma-related deaths were observed. CONCLUSIONS: In the present study, most patients underwent en bloc resection and were treated as EA cases. Both recurrences occurred in the Stage 1 tumor cohort. Therefore, although benign in character, osteochondromas still require careful management and thorough follow-up.

Original languageEnglish (US)
Pages (from-to)582-588
Number of pages7
JournalJournal of Neurosurgery: Spine
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

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Osteochondroma
Multicenter Studies
Spine
Neoplasms
Recurrence
Sacrum
Thorax
Therapeutics
Survival

Keywords

  • Neoplasm
  • Oncology
  • Osteochondroma
  • Spine
  • Tumor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sciubba, D. M., Macki, M., Bydon, M., Germscheid, N. M., Wolinsky, J. P., Boriani, S., ... Varga, P. P. (2015). Long-term outcomes in primary spinal osteochondroma: A multicenter study of 27 patients. Journal of Neurosurgery: Spine, 22(6), 582-588. https://doi.org/10.3171/2014.10.SPINE14501

Long-term outcomes in primary spinal osteochondroma : A multicenter study of 27 patients. / Sciubba, Daniel M.; Macki, Mohamed; Bydon, Mohamad; Germscheid, Niccole M.; Wolinsky, Jean Paul; Boriani, Stefano; Bettegowda, Chetan; Chou, Dean; Luzzati, Alessandro; Reynolds, Jeremy J.; Szövérfi, Zsolt; Zadnik, Patti; Rhines, Laurence D.; Gokaslan, Ziya L.; Fisher, Charles G.; Varga, Peter Paul.

In: Journal of Neurosurgery: Spine, Vol. 22, No. 6, 01.06.2015, p. 582-588.

Research output: Contribution to journalArticle

Sciubba, DM, Macki, M, Bydon, M, Germscheid, NM, Wolinsky, JP, Boriani, S, Bettegowda, C, Chou, D, Luzzati, A, Reynolds, JJ, Szövérfi, Z, Zadnik, P, Rhines, LD, Gokaslan, ZL, Fisher, CG & Varga, PP 2015, 'Long-term outcomes in primary spinal osteochondroma: A multicenter study of 27 patients', Journal of Neurosurgery: Spine, vol. 22, no. 6, pp. 582-588. https://doi.org/10.3171/2014.10.SPINE14501
Sciubba, Daniel M. ; Macki, Mohamed ; Bydon, Mohamad ; Germscheid, Niccole M. ; Wolinsky, Jean Paul ; Boriani, Stefano ; Bettegowda, Chetan ; Chou, Dean ; Luzzati, Alessandro ; Reynolds, Jeremy J. ; Szövérfi, Zsolt ; Zadnik, Patti ; Rhines, Laurence D. ; Gokaslan, Ziya L. ; Fisher, Charles G. ; Varga, Peter Paul. / Long-term outcomes in primary spinal osteochondroma : A multicenter study of 27 patients. In: Journal of Neurosurgery: Spine. 2015 ; Vol. 22, No. 6. pp. 582-588.
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AU - Wolinsky, Jean Paul

AU - Boriani, Stefano

AU - Bettegowda, Chetan

AU - Chou, Dean

AU - Luzzati, Alessandro

AU - Reynolds, Jeremy J.

AU - Szövérfi, Zsolt

AU - Zadnik, Patti

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N2 - OBJECT: Clinical outcomes in patients with primary spinal osteochondromas are limited to small series and sporadic case reports. The authors present data on the first long-term investigation of spinal osteochondroma cases. METHODS: An international, multicenter ambispective study on primary spinal osteochondroma was performed. Patients were included if they were diagnosed with an osteochondroma of the spine and received surgical treatment between October 1996 and June 2012 with at least 1 follow-up. Perioperative prognostic variables, including patient age, tumor size, spinal level, and resection, were analyzed in reference to long-term local recurrence and survival. Tumor resections were compared using Enneking appropriate (EA) or Enneking inappropriate surgical margins. RESULTS: Osteochondromas were diagnosed in 27 patients at an average age of 37 years. Twenty-two lesions were found in the mobile spine (cervical, thoracic, or lumbar) and 5 in the fixed spine (sacrum). Twenty-three cases (88%) were benign tumors (Enneking tumor Stages 1-3), whereas 3 (12%) exhibited malignant changes (Enneking tumor Stages IA-IIB). Sixteen patients (62%) underwent en bloc treatment - that is, wide or marginal resection - and 10 (38%) underwent intralesional resection. Twenty-four operations (92%) followed EA margins. No one received adjuvant therapy. Two patients (8%) experienced recurrences: one in the fixed spine and one in the mobile spine. Both recurrences occurred in latent Stage 1 tumors following en bloc resection. No osteochondroma-related deaths were observed. CONCLUSIONS: In the present study, most patients underwent en bloc resection and were treated as EA cases. Both recurrences occurred in the Stage 1 tumor cohort. Therefore, although benign in character, osteochondromas still require careful management and thorough follow-up.

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