Long-term outcome of renal transplantation in autosomal dominant polycystic kidney disease

P. M. Fitzpatrick, Vicente Torres, J. W. Charboneau, K. P. Offord, K. E. Holley, H. Zincke

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This study was performed to determine the long-term outcome of renal transplantation in 54 patients with end-stage renal failure secondary to autosomal dominant polycystic kidney disease (ADPKD) and in 107 patients with renal diseases other than ADPKD or diabetes mellitus matched by gender, age, year of transplantation, and source of the allograft. The overall patient survival and patient survival with a functioning first renal allograft were similar in both groups. Infection and cardiovascular accidents were the leading causes of early and late death in both groups. No cause of death was greatly overrepresented in the ADPKD group. Serious complications from extrarenal manifestations of ADPKD following renal transplantation included a ruptured intracranial aneurysm in one patient, a dissection of the ascending thoracic aorta in one patient, and infected hepatic cysts in two patients. Neoplasia (other than skin or cervical) occurred in four ADPKD patients and in one control patient and included one lymphoma in each group. Two ADPKD and one control patient had monoclonal gammopathies of undetermined significance. No complications related to the retention of native kidneys were detected in 12 ADPKD patients with a mean follow-up of 3 years. Cysts were observed in the renal allografts of some patients in both groups at autopsy and in a prospective computed tomography (CT) study of the allograft. However, we failed to detect a significant difference in the occurrence and number of the cysts between ADPKD and control patients.

Original languageEnglish (US)
Pages (from-to)535-543
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume15
Issue number6
StatePublished - 1990

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Autosomal Dominant Polycystic Kidney
Kidney Transplantation
Allografts
Kidney
Cysts
Cardiovascular Infections
Monoclonal Gammopathy of Undetermined Significance
Ruptured Aneurysm
Survival
Intracranial Aneurysm
Thoracic Aorta
Chronic Kidney Failure
Accidents
Aorta
Dissection
Cause of Death

ASJC Scopus subject areas

  • Nephrology

Cite this

Fitzpatrick, P. M., Torres, V., Charboneau, J. W., Offord, K. P., Holley, K. E., & Zincke, H. (1990). Long-term outcome of renal transplantation in autosomal dominant polycystic kidney disease. American Journal of Kidney Diseases, 15(6), 535-543.

Long-term outcome of renal transplantation in autosomal dominant polycystic kidney disease. / Fitzpatrick, P. M.; Torres, Vicente; Charboneau, J. W.; Offord, K. P.; Holley, K. E.; Zincke, H.

In: American Journal of Kidney Diseases, Vol. 15, No. 6, 1990, p. 535-543.

Research output: Contribution to journalArticle

Fitzpatrick, PM, Torres, V, Charboneau, JW, Offord, KP, Holley, KE & Zincke, H 1990, 'Long-term outcome of renal transplantation in autosomal dominant polycystic kidney disease', American Journal of Kidney Diseases, vol. 15, no. 6, pp. 535-543.
Fitzpatrick, P. M. ; Torres, Vicente ; Charboneau, J. W. ; Offord, K. P. ; Holley, K. E. ; Zincke, H. / Long-term outcome of renal transplantation in autosomal dominant polycystic kidney disease. In: American Journal of Kidney Diseases. 1990 ; Vol. 15, No. 6. pp. 535-543.
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