Long-term outcome of patients with POEMS syndrome: An update of the Mayo Clinic experience

Taxiarchis V. Kourelis, Francis K. Buadi, Shaji K. Kumar, Morie A. Gertz, Martha Q. Lacy, David Dingli, Ronald S. Go, Prashant Kapoor, John A. Lust, Suzanne R. Hayman, Yi Hwa, S. Vincent Rajkumar, Steven R. Zeldenrust, Stephen J. Russell, Yi Lin, Nelson Leung, Robert A. Kyle, Wilson I. Gonsalves, Angela Dispenzieri

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Over the past decade, a number of changes have occurred in the diagnostic evaluation, management, and long-term follow-up of patients with POEMS syndrome at our institution. This study included 291 patients with POEMS syndrome diagnosed at the Mayo Clinic between 1974 and 2014. Patients diagnosed after 2003 had more features of the syndrome identified at diagnosis and were more likely to receive an autologous transplant (49% versus 8%, P<0.0001) and to have achieved a hematologic complete response (CR) to treatment (41% vs 25%, P<0.0001). With 2273 person-years of follow-up, 10-year overall survival (OS) was 62% (95% C.I., 56%, 67%). On multivariate analysis, the three factors associated with superior OS were younger age (RR 0.98 [0.96-1.00]), albumin greater-than 3.2 g/dL (RR 0.5 [0.32-0.89]) and attainment of complete hematologic response (RR 0.4 [0.2, 0.9]). This study confirms the very good long-term outcomes of patients with POEMS syndrome and identifies two new prognostic risk factors: albumin at diagnosis and attainment of complete hematologic response.

Original languageEnglish (US)
Pages (from-to)585-589
Number of pages5
JournalAmerican journal of hematology
Volume91
Issue number6
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Hematology

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