Long-term outcome of patients with mutiple myeloma-related advanced renal failure following auto-SCT

S. V. Glavey, M. A. Gertz, A. Dispenzieri, S. Kumar, F. Buadi, M. Lacy, S. R. Hayman, D. Dingli, A. Mccurdy, W. J. Hogan, D. A. Gastineau, N. Leung

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Renal failure commonly complicates multiple myeloma (MM) and is associated with reduced survival. It is not clear whether auto-SCT results in improved renal function or attainment of independence from dialysis in patients with advanced renal impairment due to MM. We conducted a retrospective cohort study of all patients who underwent auto-SCT for MM complicated by advanced renal failure at our institution over a 10-year period (2000-2010). We aimed to assess the association between auto-SCT and renal outcome in patients with serum creatinine (SCr) over 3 mg/dL, attributable to MM, including those who were dialysis dependent. Thirty patients (2.8% of all auto-SCT patients) met inclusion criteria. Fourteen of 15 patients who were dialysis dependent before auto-SCT remained dialysis dependent in the long term despite hematological response (HR). Of the remaining 15 patients with SCr >3 mg/dL, an improvement in glomerular filtration rate (GFR) from 15 to 19.4 mL/min/1.73 m 2 was noted post auto-SCT (P=0.035); however, neither HR post auto-SCT or pre-existing renal function were independently associated with renal outcome. Auto-SCT was not associated with independence from dialysis in patients with renal failure due to MM at our institution. Although auto-SCT was associated with an improvement in GFR in patients with SCr >3 mg/dL, this improvement was not related to HR.

Original languageEnglish (US)
Pages (from-to)1543-1547
Number of pages5
JournalBone Marrow Transplantation
Volume48
Issue number12
DOIs
StatePublished - Dec 1 2013

Keywords

  • auto-SCT
  • dialysis
  • renal

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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