Long-term outcome of globus pallidus internus deep brain stimulation in patients with tourette syndrome

Jian Guo Zhang, Yan Ge, Matt Stead, Kai Zhang, Shuang Shuang Yan, Wei Hu, Fan Gang Meng

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Objective To evaluate the effectiveness of deep brain stimulation (DBS) of the globus pallidus internus (GPi) on tic severity and common comorbidities in patients with severe Tourette syndrome that is refractory to pharmacological treatment and psychotherapy.

Patients and Methods We retrospectively assessed the long-term clinical outcomes of 13 patients with treatment-refractory Tourette syndrome who underwent DBS targeting the GPi at the Beijing Tiantan Hospital from January 1, 2006, through May 31, 2013. The primary outcome was a change in tic severity as measured by the Yale Global Tic Severity Scale, and the secondary outcome was a change in associated behavioral disorders and mood as measured by the Gilles de la Tourette Syndrome-Quality of Life Scale assessment.

Results Compared with baseline, the mean reduction in the total Yale Global Tic Severity Scale scores at last follow-up (mean, 41.9 months; range, 13-80 months) was 52.1% (range, 4.3%-83.6%), and the mean improvement rates at 1 month, 6 months, 12 months, 18 months, 24 months, 30 months, and 36 or more months were 11.8%, 20.0%, 26.8%, 36.7%, 44.7%, 49.0%, and 56.7%, respectively. A paired-sample t test revealed significant improvement of tic symptoms after 6 months of DBS programming (P<.05). The Gilles de la Tourette Syndrome-Quality of Life Scale score improved by a mean of 45.7% (range, 11.0%-77.2%).

Conclusion This study is currently the largest reported GPi DBS case series of patients with treatment-refractory TS with the longest follow-up. Our results support the potential beneficial effect of GPi DBS on disabling tic reduction and improvement of quality of life.

Original languageEnglish (US)
Pages (from-to)1506-1514
Number of pages9
JournalMayo Clinic proceedings
Volume89
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • Abbreviations and Acronyms CM-Pfc centromedian-parafascicular complex DBS deep brain stimulation GPi globus pallidus internus TS Tourette syndrome TSQOL Gilles de la Tourette Syndrome-Quality of Life Scale YGTSS Yale Global Tic Severity Scale

ASJC Scopus subject areas

  • Medicine(all)

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