Long-term incidence of glioma in Olmsted County, Minnesota, and disparities in postglioma survival rate: A population-based study

Conor S. Ryan, Young J Juhn, Harsheen Kaur, Chung Il Wi, Euijung Ryu, Katherine S. King, Daniel H Lachance

Research output: Contribution to journalArticle

Abstract

Background: We assessed glioma incidence and disparities in postglioma survival rate in the Olmsted County, Minnesota, population. Methods: This population-based study assessed the incidence of pathologically confirmed primary gliomas between January 1, 1995, and December 31, 2014. Age- and sex-adjusted incidence rates per 100 000 person-years were calculated and standardized to the US white 2010 population. We compared incidence trends of glioma during our study period with previously published Olmsted County data from 1950 to 1990. We assessed postglioma survival rates among individuals with different socioeconomic status (SES), which was measured by a validated individual HOUsing-based SES index (HOUSES). Results: We identified 135 incident glioma cases (93% white) with 20 pediatric (50% female) and 115 adult cases (44% female). Overall incidence rate during our study period, 5.51 per 100 000 person-years (95% CI: 4.56-6.46), showed no significant changes and was similar to that seen in 1950 to 1990, 5.5 per 100 000 person-years. The incidence of pediatric (age < 20 years) glioma was 2.49 (95% CI: 1.40-3.58), whereas adult glioma incidence was 6.47 (95% CI: 5.26-7.67). Among those with grade II to IV gliomas, individuals with lower SES (< median HOUSES) had significantly lower 5-year survival rates compared to those with higher SES, adjusted hazard ratio 1.61 (95% CI: 1.01-2.85). Conclusion: In a well-defined North American population, long-term glioma incidence appears stable since 1950. Significant socioeconomic disparities exist for postglioma survival.

Original languageEnglish (US)
Pages (from-to)288-298
Number of pages11
JournalNeuro-Oncology Practice
Volume7
Issue number3
DOIs
StatePublished - Jun 5 2020

Keywords

  • astrocytoma
  • glioblastoma
  • mortality
  • pediatric
  • socioeconomic

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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