Long-term healing of photodynamic therapy: treatment of experimental intimal hyperplasia

Glenn M MD LaMuraglia, N. R MD ChandraSekar, Thomas J Flotte, Tayyaba Hasan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A study was performed to determine whether intimal hyperplasia can be chronically inhibited and the artery wall integrity maintained after cells are depleted from the artery with photodynamic therapy. Utilizing chloroaluminum sulfonated phthalocyanine or saline for control, limited balloon injury of the common carotid artery was performed before irradiation with 675 mm laser light. Results demonstrated carotid inhibition of intimal hyperplasia in PDT treated arteries without aneurysm formation or artery dilatation. By 4 weeks there was reendothelialization of the intima of the PDT arteries and repopulation of the adventitia with myofibroblasts. This data was encouraging in that PDT can chronically inhibit intimal hyperplasia without precipitating a weakness in the arterial wall.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsGeorge S. Abela
Pages25-29
Number of pages5
Volume2130
StatePublished - 1994
Externally publishedYes
EventProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV - Los Angeles, CA, USA
Duration: Jan 22 1994Jan 23 1994

Other

OtherProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV
CityLos Angeles, CA, USA
Period1/22/941/23/94

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    LaMuraglia, G. M. MD., ChandraSekar, N. R. MD., Flotte, T. J., & Hasan, T. (1994). Long-term healing of photodynamic therapy: treatment of experimental intimal hyperplasia. In G. S. Abela (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2130, pp. 25-29)