Long-term fracture risk in patients with celiac disease: A population-based study in Olmsted County, Minnesota

Mohammed R. Jafri, Charles W. Nordstrom, Joseph A. Murray, Carol T. Van Dyke, Ross A. Dierkhising, Alan R. Zinsmeister, Lee J. Melton

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Celiac disease is associated with decreased bone density, but there are conflicting data regarding fracture risk. We determined the fracture incidence relative to matched controls in a population-based cohort with celiac disease before and after diagnosis. Olmsted County residents with celiac disease (n = 83) diagnosed between 1950 and 2002 were compared with 166 gender and age matched controls. Fracture histories were ascertained from each subject's medical records. Celiac disease is linked to an increased fracture risk before and after diagnosis. Before the index date, cases had a fracture rate twice that of controls (CI: 1.0-3.9, P = 0.045) and 2.5-fold greater after the index date (CI: 1.1-5.6, P = 0.026). Appendicular and axial fractures were 2.5 (CI: 0.9-6.5) and 3.2 times more likely (CI: 1.0-10.5) after the index date. These observations support a rationale for earlier detection of celiac disease, and active management of bone disease before bone effects have occurred, to reduce the persistent risk of fractures.

Original languageEnglish (US)
Pages (from-to)964-971
Number of pages8
JournalDigestive diseases and sciences
Volume53
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Fractures
  • Osteomalacia
  • Osteoporosis
  • Outcome
  • Sprue

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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