@article{290e623291ff4bceaa6085a93c3f68f1,
title = "Long-Term Follow-up of Hypophosphatemic Bone Disease Associated With Elemental Formula Use: Sustained Correction of Bone Disease After Formula Change or Phosphate Supplementation",
abstract = "In this article, we describe the long-term outcomes of children who were previously reported to have developed hypophosphatemic bone disease in association with elemental formula use. An extended chart review allowed for an updated report of 34 children with regard to severity/duration of bone disease, extent of recovery, and time to correction using radiology reports and biochemical data. After implementation of formula change and/or phosphate supplementation, we found that serum phosphorus concentration increased and serum alkaline phosphatase activity decreased in all patients, normalizing by 6.6 ± 4.0 (mean ± SD) months following diagnosis. The decrease in serum alkaline phosphatase from diagnosis to the time of correction was moderately correlated with the concurrent increase in serum phosphorus (R = 0.48, P <.05). Age at diagnosis significantly correlated with time to resolution (R = 0.51, P =.01). This study supports the earlier report that bone disease associated with hypophosphatemia during elemental formula use responds to formula change and/or phosphate supplementation.",
keywords = "amino acid–based elemental formula, hypophosphatemia, nutrition, phosphate bioavailability, rickets",
author = "Eswarakumar, {Abigail S.} and Ma, {Nina S.} and Ward, {Leanne M.} and Philippe Backeljauw and Halley Wasserman and Weber, {David R.} and DiMeglio, {Linda A.} and Imel, {Erik A.} and Julie Gagne and Declan Cody and Paul Zimakas and Topor, {Lisa Swartz} and Sungeeta Agrawal and Andrew Calabria and Peter Tebben and Faircloth, {Ruth S.} and Rebecca Gordon and Linda Casey and Carpenter, {Thomas O.}",
note = "Funding Information: We acknowledge Dr Ma{\textquoteright}s support as the Ed and Jeannette Kerr Family Endowed Chair in Endocrinology at the Children{\textquoteright}s Hospital of Colorado. The research was performed with appropriate approval at each of the participating centers. Dedicated protocol numbers were obtained where required (Boston Children{\textquoteright}s Hospital Institutional Review Board, Boston, MA, Irb-p00030879; British Columbia Children{\textquoteright}s Hospital, University of British Columbia C&W Research Ethics Board, Vancouver, BC, H19-00726; Yale University School of Medicine Human Investigation Committee, New Haven, CT, 000024776). Institutional review boards allowing medical record review/case reports without a dedicated protocol included those at the Children{\textquoteright}s Hospital of Eastern Ontario (Ottawa, ON); Cincinnati Children{\textquoteright}s Hospital Medical Center and University of Cincinnati College of Medicine (Cincinnati, OH); University of Rochester (Rochester, NY); Riley Hospital for Children, Indiana University School of Medicine (Indianapolis, IN); Centre Hospitalier de l{\textquoteright}Universit{\'e} Laval (Quebec City, QC); Our Lady{\textquoteright}s Children{\textquoteright}s Hospital (Crumlin, Ireland); University of Vermont Medical Center (Burlington, VT); Alpert Medical School of Brown University and Hasbro Children{\textquoteright}s Hospital (Providence, RI); Children{\textquoteright}s Hospital of Philadelphia (Philadelphia, PA); Columbia University Medical Center (New York, NY); Mayo Clinic (Rochester, MN); and Walter Reed National Military Medical Center (Bethesda, MD). The author(s) received no financial support for the research, authorship, and/or publication of this article. Publisher Copyright: {\textcopyright} The Author(s) 2020.",
year = "2020",
month = oct,
day = "1",
doi = "10.1177/0009922820941097",
language = "English (US)",
volume = "59",
pages = "1080--1085",
journal = "Clinical Pediatrics",
issn = "0009-9228",
publisher = "SAGE Publications Inc.",
number = "12",
}