Long-term follow-up in repaired tetralogy of Fallot: Can deformation imaging help identify optimal timing of pulmonary valve replacement?

Anna Sabate Rotes, Crystal R. Bonnichsen, Chelsea L. Reece, Heidi M. Connolly, Harold M. Burkhart, Joseph A. Dearani, Benjamin W. Eidem

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background Novel echocardiographic techniques based on myocardial deformation have not been extensively evaluated to assess right ventricular (RV) and left ventricular (LV) response after pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot.

Methods Between 2003 and 2012, 133 patients undergoing first-time PVR after tetralogy of Fallot repair underwent echocardiographic assessment at Mayo Clinic. The last echocardiogram before PVR and 1 year after surgery were retrospectively analyzed with Velocity Vector Imaging.

Results Mean age at PVR was 35.5 ± 16.2 years (54% women). Longitudinal peak systolic strain and strain rate before PVR were low: for the left ventricle, -14.8 ± 3.5% and -0.8 ± 0.2 sec-1, and for the right ventricle, -16.2 ± 4.1% and -0.9 ± 0.3 sec-1, respectively. There was no significant change in either parameter after surgery. A close correlation between LV and RV deformational parameters was found before PVR and was maintained after surgery. In the multivariate analysis, patients with better LV and RV peak systolic strain preoperatively were found to have better LV and RV peak systolic strain after surgery (P =.004 and P =.006, respectively). However, patients with the most improvement in deformation were those with worse RV function preoperatively (P =.002). Mean New York Heart Association class at early follow-up improved from 2.2 ± 0.8 to 1.2 ± 0.6 (P <.0001); RV peak systolic strain was the only factor associated with symptomatic improvement.

Conclusion LV and RV systolic and diastolic deformational parameters were decreased in patients with repaired tetralogy of Fallot undergoing PVR, and there was no significant change after surgery. However, preoperative systolic deformational parameters were predictive of postoperative ventricular function and New York Heart Association class after PVR and may be helpful to identify optimal timing for surgical intervention in this cohort.

Original languageEnglish (US)
Pages (from-to)1305-1310
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2014

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Pulmonary Valve
Tetralogy of Fallot
Heart Ventricles
Right Ventricular Function
Ventricular Function
Multivariate Analysis

Keywords

  • Fallot
  • Magnetic resonance imaging
  • Pulmonary valve replacement
  • Strain echocardiography
  • Tetralogy of

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Long-term follow-up in repaired tetralogy of Fallot : Can deformation imaging help identify optimal timing of pulmonary valve replacement? / Sabate Rotes, Anna; Bonnichsen, Crystal R.; Reece, Chelsea L.; Connolly, Heidi M.; Burkhart, Harold M.; Dearani, Joseph A.; Eidem, Benjamin W.

In: Journal of the American Society of Echocardiography, Vol. 27, No. 12, 01.12.2014, p. 1305-1310.

Research output: Contribution to journalArticle

Sabate Rotes, Anna ; Bonnichsen, Crystal R. ; Reece, Chelsea L. ; Connolly, Heidi M. ; Burkhart, Harold M. ; Dearani, Joseph A. ; Eidem, Benjamin W. / Long-term follow-up in repaired tetralogy of Fallot : Can deformation imaging help identify optimal timing of pulmonary valve replacement?. In: Journal of the American Society of Echocardiography. 2014 ; Vol. 27, No. 12. pp. 1305-1310.
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abstract = "Background Novel echocardiographic techniques based on myocardial deformation have not been extensively evaluated to assess right ventricular (RV) and left ventricular (LV) response after pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot.Methods Between 2003 and 2012, 133 patients undergoing first-time PVR after tetralogy of Fallot repair underwent echocardiographic assessment at Mayo Clinic. The last echocardiogram before PVR and 1 year after surgery were retrospectively analyzed with Velocity Vector Imaging.Results Mean age at PVR was 35.5 ± 16.2 years (54{\%} women). Longitudinal peak systolic strain and strain rate before PVR were low: for the left ventricle, -14.8 ± 3.5{\%} and -0.8 ± 0.2 sec-1, and for the right ventricle, -16.2 ± 4.1{\%} and -0.9 ± 0.3 sec-1, respectively. There was no significant change in either parameter after surgery. A close correlation between LV and RV deformational parameters was found before PVR and was maintained after surgery. In the multivariate analysis, patients with better LV and RV peak systolic strain preoperatively were found to have better LV and RV peak systolic strain after surgery (P =.004 and P =.006, respectively). However, patients with the most improvement in deformation were those with worse RV function preoperatively (P =.002). Mean New York Heart Association class at early follow-up improved from 2.2 ± 0.8 to 1.2 ± 0.6 (P <.0001); RV peak systolic strain was the only factor associated with symptomatic improvement.Conclusion LV and RV systolic and diastolic deformational parameters were decreased in patients with repaired tetralogy of Fallot undergoing PVR, and there was no significant change after surgery. However, preoperative systolic deformational parameters were predictive of postoperative ventricular function and New York Heart Association class after PVR and may be helpful to identify optimal timing for surgical intervention in this cohort.",
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T2 - Can deformation imaging help identify optimal timing of pulmonary valve replacement?

AU - Sabate Rotes, Anna

AU - Bonnichsen, Crystal R.

AU - Reece, Chelsea L.

AU - Connolly, Heidi M.

AU - Burkhart, Harold M.

AU - Dearani, Joseph A.

AU - Eidem, Benjamin W.

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N2 - Background Novel echocardiographic techniques based on myocardial deformation have not been extensively evaluated to assess right ventricular (RV) and left ventricular (LV) response after pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot.Methods Between 2003 and 2012, 133 patients undergoing first-time PVR after tetralogy of Fallot repair underwent echocardiographic assessment at Mayo Clinic. The last echocardiogram before PVR and 1 year after surgery were retrospectively analyzed with Velocity Vector Imaging.Results Mean age at PVR was 35.5 ± 16.2 years (54% women). Longitudinal peak systolic strain and strain rate before PVR were low: for the left ventricle, -14.8 ± 3.5% and -0.8 ± 0.2 sec-1, and for the right ventricle, -16.2 ± 4.1% and -0.9 ± 0.3 sec-1, respectively. There was no significant change in either parameter after surgery. A close correlation between LV and RV deformational parameters was found before PVR and was maintained after surgery. In the multivariate analysis, patients with better LV and RV peak systolic strain preoperatively were found to have better LV and RV peak systolic strain after surgery (P =.004 and P =.006, respectively). However, patients with the most improvement in deformation were those with worse RV function preoperatively (P =.002). Mean New York Heart Association class at early follow-up improved from 2.2 ± 0.8 to 1.2 ± 0.6 (P <.0001); RV peak systolic strain was the only factor associated with symptomatic improvement.Conclusion LV and RV systolic and diastolic deformational parameters were decreased in patients with repaired tetralogy of Fallot undergoing PVR, and there was no significant change after surgery. However, preoperative systolic deformational parameters were predictive of postoperative ventricular function and New York Heart Association class after PVR and may be helpful to identify optimal timing for surgical intervention in this cohort.

AB - Background Novel echocardiographic techniques based on myocardial deformation have not been extensively evaluated to assess right ventricular (RV) and left ventricular (LV) response after pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot.Methods Between 2003 and 2012, 133 patients undergoing first-time PVR after tetralogy of Fallot repair underwent echocardiographic assessment at Mayo Clinic. The last echocardiogram before PVR and 1 year after surgery were retrospectively analyzed with Velocity Vector Imaging.Results Mean age at PVR was 35.5 ± 16.2 years (54% women). Longitudinal peak systolic strain and strain rate before PVR were low: for the left ventricle, -14.8 ± 3.5% and -0.8 ± 0.2 sec-1, and for the right ventricle, -16.2 ± 4.1% and -0.9 ± 0.3 sec-1, respectively. There was no significant change in either parameter after surgery. A close correlation between LV and RV deformational parameters was found before PVR and was maintained after surgery. In the multivariate analysis, patients with better LV and RV peak systolic strain preoperatively were found to have better LV and RV peak systolic strain after surgery (P =.004 and P =.006, respectively). However, patients with the most improvement in deformation were those with worse RV function preoperatively (P =.002). Mean New York Heart Association class at early follow-up improved from 2.2 ± 0.8 to 1.2 ± 0.6 (P <.0001); RV peak systolic strain was the only factor associated with symptomatic improvement.Conclusion LV and RV systolic and diastolic deformational parameters were decreased in patients with repaired tetralogy of Fallot undergoing PVR, and there was no significant change after surgery. However, preoperative systolic deformational parameters were predictive of postoperative ventricular function and New York Heart Association class after PVR and may be helpful to identify optimal timing for surgical intervention in this cohort.

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KW - Magnetic resonance imaging

KW - Pulmonary valve replacement

KW - Strain echocardiography

KW - Tetralogy of

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