Long-term endurance training alters the hypothalamic-pituitary axes for gonadotropins and growth hormone

A. D. Rogol, J. Y. Weltman, W. S. Evans, Johannes D Veldhuis, A. L. Weltman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In a prospective fashion we have studied the impact of chronic exercise of two intensities on the hypothalamic-pituitary-end organ axes for gonadotropins and GH in gynecologically mature, previously sedentary women. Physiologic alterations are evident in both axes with a doubling of 24-hour mean serum GH concentrations at 1 year and smaller, transient changes in pulsatile LH release during the first four menstrual cycles. The latter period of physiologic adaptation should be studied more intensively with more frequent exercise evaluation. Perhaps more significant 'adaptation to stress' would be quantitated. We also emphasize that gynecologically less mature women were not studied and only the early follicular phase was evaluated. Adaptive changes of greater magnitude (including amenorrhea) might have been produced if a different group of women, a markedly different training regimen, or a different phase of the menstrual cycle were studied. Finally, whether or not they participate in physical training, younger amenorrheic women are at increased risk for diminished lumbar spine bone mineral content and skeletal fractures.

Original languageEnglish (US)
Pages (from-to)817-832
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Volume21
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Pituitary Gonadotropins
Gonadotropins
Growth Hormone
Minerals
Bone
Durability
Menstrual Cycle
Exercise
Physiological Adaptation
Follicular Phase
Amenorrhea
Bone Density
Spine
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Rogol, A. D., Weltman, J. Y., Evans, W. S., Veldhuis, J. D., & Weltman, A. L. (1992). Long-term endurance training alters the hypothalamic-pituitary axes for gonadotropins and growth hormone. Endocrinology and Metabolism Clinics of North America, 21(4), 817-832.

Long-term endurance training alters the hypothalamic-pituitary axes for gonadotropins and growth hormone. / Rogol, A. D.; Weltman, J. Y.; Evans, W. S.; Veldhuis, Johannes D; Weltman, A. L.

In: Endocrinology and Metabolism Clinics of North America, Vol. 21, No. 4, 1992, p. 817-832.

Research output: Contribution to journalArticle

Rogol, A. D. ; Weltman, J. Y. ; Evans, W. S. ; Veldhuis, Johannes D ; Weltman, A. L. / Long-term endurance training alters the hypothalamic-pituitary axes for gonadotropins and growth hormone. In: Endocrinology and Metabolism Clinics of North America. 1992 ; Vol. 21, No. 4. pp. 817-832.
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