Long-term clinical and angiographic outcomes in patients with diabetes undergoing coronary artery bypass graft surgery: Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV Trial

Masaya Koshizaka, Renato D. Lopes, Eric M. Reyes, C. Michael Gibson, Phillip Schulte, Gail E. Hafley, Adrian F. Hernandez, Jennifer B. Green, Nicholas T. Kouchoukos, Robert M. Califf, T. Bruce Ferguson, Eric D. Peterson, John H. Alexander

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background There is limited information about the association between diabetes, its treatment, and long-term angiographic and clinical outcomes in patients undergoing coronary artery bypass graft surgery (CABG). We evaluated the association of diabetes and its treatment with 1-year angiographic graft failure and 5-year clinical outcomes in patients undergoing CABG. Methods Using data from 3,014 patients in PREVENT IV, we analyzed angiographic and clinical outcomes in patients with and without diabetes and among those who did and did not receive insulin before CABG. Logistic regression and Cox proportional hazards models were used to adjust for differences in baseline variables. Results Overall, 1,139 (37.8%) patients had diabetes. Of these, 305 (26.8%) received insulin. One-year rates of vein graft failure were similar in patients with and without diabetes but, among diabetics, tended to be higher in patients who received insulin compared with those who did not. At 5 years, rates of death, myocardial infarction, or revascularization were higher among patients with compared with those without diabetes (adjusted hazard ratio 1.57; 95% CI 1.26-1.96; P b .001) and, among diabetics, higher among those who received insulin (adjusted hazard ratio 1.15; 95% CI 1.02-1.30; P = .02). Conclusions Patients with diabetes had similar rates of vein graft failure but worse clinical outcomes than patients without diabetes. Patients who received insulin had significantly worse clinical outcomes than patients who did not receive insulin. Further studies to better understand the mechanism behind these findings and to improve the outcomes of patients with insulin-requiring diabetes undergoing CABG surgery are warranted.

Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalAmerican Heart Journal
Volume169
Issue number1
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Coronary Artery Bypass
Transfection
Veins
Transplants
Insulin
Myocardial Revascularization
Proportional Hazards Models
Logistic Models
Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Long-term clinical and angiographic outcomes in patients with diabetes undergoing coronary artery bypass graft surgery : Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV Trial. / Koshizaka, Masaya; Lopes, Renato D.; Reyes, Eric M.; Gibson, C. Michael; Schulte, Phillip; Hafley, Gail E.; Hernandez, Adrian F.; Green, Jennifer B.; Kouchoukos, Nicholas T.; Califf, Robert M.; Ferguson, T. Bruce; Peterson, Eric D.; Alexander, John H.

In: American Heart Journal, Vol. 169, No. 1, 2014, p. 175-184.

Research output: Contribution to journalArticle

Koshizaka, M, Lopes, RD, Reyes, EM, Gibson, CM, Schulte, P, Hafley, GE, Hernandez, AF, Green, JB, Kouchoukos, NT, Califf, RM, Ferguson, TB, Peterson, ED & Alexander, JH 2014, 'Long-term clinical and angiographic outcomes in patients with diabetes undergoing coronary artery bypass graft surgery: Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV Trial', American Heart Journal, vol. 169, no. 1, pp. 175-184. https://doi.org/10.1016/j.ahj.2014.10.013
Koshizaka, Masaya ; Lopes, Renato D. ; Reyes, Eric M. ; Gibson, C. Michael ; Schulte, Phillip ; Hafley, Gail E. ; Hernandez, Adrian F. ; Green, Jennifer B. ; Kouchoukos, Nicholas T. ; Califf, Robert M. ; Ferguson, T. Bruce ; Peterson, Eric D. ; Alexander, John H. / Long-term clinical and angiographic outcomes in patients with diabetes undergoing coronary artery bypass graft surgery : Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV Trial. In: American Heart Journal. 2014 ; Vol. 169, No. 1. pp. 175-184.
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abstract = "Background There is limited information about the association between diabetes, its treatment, and long-term angiographic and clinical outcomes in patients undergoing coronary artery bypass graft surgery (CABG). We evaluated the association of diabetes and its treatment with 1-year angiographic graft failure and 5-year clinical outcomes in patients undergoing CABG. Methods Using data from 3,014 patients in PREVENT IV, we analyzed angiographic and clinical outcomes in patients with and without diabetes and among those who did and did not receive insulin before CABG. Logistic regression and Cox proportional hazards models were used to adjust for differences in baseline variables. Results Overall, 1,139 (37.8{\%}) patients had diabetes. Of these, 305 (26.8{\%}) received insulin. One-year rates of vein graft failure were similar in patients with and without diabetes but, among diabetics, tended to be higher in patients who received insulin compared with those who did not. At 5 years, rates of death, myocardial infarction, or revascularization were higher among patients with compared with those without diabetes (adjusted hazard ratio 1.57; 95{\%} CI 1.26-1.96; P b .001) and, among diabetics, higher among those who received insulin (adjusted hazard ratio 1.15; 95{\%} CI 1.02-1.30; P = .02). Conclusions Patients with diabetes had similar rates of vein graft failure but worse clinical outcomes than patients without diabetes. Patients who received insulin had significantly worse clinical outcomes than patients who did not receive insulin. Further studies to better understand the mechanism behind these findings and to improve the outcomes of patients with insulin-requiring diabetes undergoing CABG surgery are warranted.",
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T1 - Long-term clinical and angiographic outcomes in patients with diabetes undergoing coronary artery bypass graft surgery

T2 - Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV Trial

AU - Koshizaka, Masaya

AU - Lopes, Renato D.

AU - Reyes, Eric M.

AU - Gibson, C. Michael

AU - Schulte, Phillip

AU - Hafley, Gail E.

AU - Hernandez, Adrian F.

AU - Green, Jennifer B.

AU - Kouchoukos, Nicholas T.

AU - Califf, Robert M.

AU - Ferguson, T. Bruce

AU - Peterson, Eric D.

AU - Alexander, John H.

PY - 2014

Y1 - 2014

N2 - Background There is limited information about the association between diabetes, its treatment, and long-term angiographic and clinical outcomes in patients undergoing coronary artery bypass graft surgery (CABG). We evaluated the association of diabetes and its treatment with 1-year angiographic graft failure and 5-year clinical outcomes in patients undergoing CABG. Methods Using data from 3,014 patients in PREVENT IV, we analyzed angiographic and clinical outcomes in patients with and without diabetes and among those who did and did not receive insulin before CABG. Logistic regression and Cox proportional hazards models were used to adjust for differences in baseline variables. Results Overall, 1,139 (37.8%) patients had diabetes. Of these, 305 (26.8%) received insulin. One-year rates of vein graft failure were similar in patients with and without diabetes but, among diabetics, tended to be higher in patients who received insulin compared with those who did not. At 5 years, rates of death, myocardial infarction, or revascularization were higher among patients with compared with those without diabetes (adjusted hazard ratio 1.57; 95% CI 1.26-1.96; P b .001) and, among diabetics, higher among those who received insulin (adjusted hazard ratio 1.15; 95% CI 1.02-1.30; P = .02). Conclusions Patients with diabetes had similar rates of vein graft failure but worse clinical outcomes than patients without diabetes. Patients who received insulin had significantly worse clinical outcomes than patients who did not receive insulin. Further studies to better understand the mechanism behind these findings and to improve the outcomes of patients with insulin-requiring diabetes undergoing CABG surgery are warranted.

AB - Background There is limited information about the association between diabetes, its treatment, and long-term angiographic and clinical outcomes in patients undergoing coronary artery bypass graft surgery (CABG). We evaluated the association of diabetes and its treatment with 1-year angiographic graft failure and 5-year clinical outcomes in patients undergoing CABG. Methods Using data from 3,014 patients in PREVENT IV, we analyzed angiographic and clinical outcomes in patients with and without diabetes and among those who did and did not receive insulin before CABG. Logistic regression and Cox proportional hazards models were used to adjust for differences in baseline variables. Results Overall, 1,139 (37.8%) patients had diabetes. Of these, 305 (26.8%) received insulin. One-year rates of vein graft failure were similar in patients with and without diabetes but, among diabetics, tended to be higher in patients who received insulin compared with those who did not. At 5 years, rates of death, myocardial infarction, or revascularization were higher among patients with compared with those without diabetes (adjusted hazard ratio 1.57; 95% CI 1.26-1.96; P b .001) and, among diabetics, higher among those who received insulin (adjusted hazard ratio 1.15; 95% CI 1.02-1.30; P = .02). Conclusions Patients with diabetes had similar rates of vein graft failure but worse clinical outcomes than patients without diabetes. Patients who received insulin had significantly worse clinical outcomes than patients who did not receive insulin. Further studies to better understand the mechanism behind these findings and to improve the outcomes of patients with insulin-requiring diabetes undergoing CABG surgery are warranted.

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