Long-Term Antioxidant Intervention Improves Myocardial Microvascular Function in Experimental Hypertension

Martin G Rodriguez-Porcel, Joerg Herrmann, Alejandro R. Chade, James D. Krier, Jerome F. Breen, Amir Lerman, Lilach O Lerman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Hypertension increases oxidative stress, which can impair myocardial microvascular function and integrity. However, it is yet unclear whether long-term antioxidant intervention in early hypertension would preserve myocardial perfusion and vascular permeability responses to challenge. Pigs were studied after 12 weeks of renovascular hypertension without (n=8) or with daily supplementation of antioxidants (100 IU/kg vitamin E and 1 g vitamin C, n=6), and compared with normal controls (n=7). Myocardial perfusion and microvascular permeability were measured in vivo by electron beam computed tomography before and after 2 cardiac challenges (intravenous adenosine and dobutamine). Basal left ventricular muscle mass was also obtained. Mean arterial pressure was significantly increased in both groups of hypertensive animals (without and with antioxidants, 123±9 and 126±4 mm Hg, respectively, versus normal, 101±4 mm Hg; both P<0.05), but muscle mass was not different among the groups. The impaired myocardial perfusion response to adenosine observed in hypertensives (normal, +51±14%; P<0.05 versus baseline; hypertension, +14±15%; P=0.3 versus baseline) was preserved in hypertensive pigs that received antioxidants (+44±15%; P=0.01 compared with baseline). Long-term antioxidant intervention also preserved subendocardial microvascular permeability responses in hypertension. On the other hand, antioxidant intervention had little effect on the hypertension-induced myocardial vascular dysfunction observed in response to dobutamine. This study demonstrates that the impaired myocardial perfusion and permeability responses to increased cardiac demand in early hypertension are significantly improved by long-term antioxidant intervention. These results support the involvement of oxidative stress in myocardial vascular dysfunction in hypertension and suggest a role for antioxidant strategies to preserve the myocardial microvasculature.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalHypertension
Volume43
Issue number2 II
DOIs
StatePublished - Feb 2004

Fingerprint

Antioxidants
Hypertension
Capillary Permeability
Perfusion
Dobutamine
Adenosine
Blood Vessels
Oxidative Stress
Swine
Muscles
Renovascular Hypertension
X Ray Computed Tomography
Microvessels
Vitamin E
Ascorbic Acid
Permeability
Arterial Pressure

Keywords

  • Antioxidants
  • Hypertension, experimental
  • Imaging
  • Oxidative stress

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Long-Term Antioxidant Intervention Improves Myocardial Microvascular Function in Experimental Hypertension. / Rodriguez-Porcel, Martin G; Herrmann, Joerg; Chade, Alejandro R.; Krier, James D.; Breen, Jerome F.; Lerman, Amir; Lerman, Lilach O.

In: Hypertension, Vol. 43, No. 2 II, 02.2004, p. 493-498.

Research output: Contribution to journalArticle

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