Long-term alterations in growth factor mRNA expression following seizures

Michael L. Garcia, Virginia B. Garcia, Paul J. Isackson, Anthony John Windebank

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

ALTHOUGH alterations in growth factor mRNA occur during neuronal insults, little is known about the long-term effects of neuronal insults on growth factor expression. We have examined the effects of prolonged post- ictal times on the expression of Brain-derivered nerve factor (BDNF) and Neurotrophin 3 (NT3) following Kainic acid (KA)-induced seizures. In situ hybridization was performed on male Sprague-Dawley rats sacrificed 1-2 weeks following intracranial ventricular KA injections. BDNF mRNA increased bilaterally 1 and 2 weeks after injections, whereas NT3 mRNA decreased contralaterally 1 week and bilaterally 2 weeks post-injection. These observations provide evidence that alterations in growth factor mRNA expression occur even after prolonged post-ictal recovery suggesting a possible role for growth factors in recovery and continued maintenance of surviving neurons within limbic seizure foci.

Original languageEnglish (US)
Pages (from-to)1445-1449
Number of pages5
JournalNeuroReport
Volume8
Issue number6
StatePublished - 1997

Fingerprint

Intercellular Signaling Peptides and Proteins
Seizures
Neurotrophin 3
Messenger RNA
Kainic Acid
Injections
Stroke
Brain
In Situ Hybridization
Sprague Dawley Rats
Maintenance
Neurons

Keywords

  • Brain-derived nerve factor (BDNF)
  • Hippocampus
  • Kainic acid
  • Neurotrophin 3 (NT3)
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Garcia, M. L., Garcia, V. B., Isackson, P. J., & Windebank, A. J. (1997). Long-term alterations in growth factor mRNA expression following seizures. NeuroReport, 8(6), 1445-1449.

Long-term alterations in growth factor mRNA expression following seizures. / Garcia, Michael L.; Garcia, Virginia B.; Isackson, Paul J.; Windebank, Anthony John.

In: NeuroReport, Vol. 8, No. 6, 1997, p. 1445-1449.

Research output: Contribution to journalArticle

Garcia, ML, Garcia, VB, Isackson, PJ & Windebank, AJ 1997, 'Long-term alterations in growth factor mRNA expression following seizures', NeuroReport, vol. 8, no. 6, pp. 1445-1449.
Garcia, Michael L. ; Garcia, Virginia B. ; Isackson, Paul J. ; Windebank, Anthony John. / Long-term alterations in growth factor mRNA expression following seizures. In: NeuroReport. 1997 ; Vol. 8, No. 6. pp. 1445-1449.
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