Long-term alterations in growth factor mRNA expression following seizures

Michael L. Garcia, Virginia B. Garcia, Paul J. Isackson, Anthony J. Windebank

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


ALTHOUGH alterations in growth factor mRNA occur during neuronal insults, little is known about the long-term effects of neuronal insults on growth factor expression. We have examined the effects of prolonged post- ictal times on the expression of Brain-derivered nerve factor (BDNF) and Neurotrophin 3 (NT3) following Kainic acid (KA)-induced seizures. In situ hybridization was performed on male Sprague-Dawley rats sacrificed 1-2 weeks following intracranial ventricular KA injections. BDNF mRNA increased bilaterally 1 and 2 weeks after injections, whereas NT3 mRNA decreased contralaterally 1 week and bilaterally 2 weeks post-injection. These observations provide evidence that alterations in growth factor mRNA expression occur even after prolonged post-ictal recovery suggesting a possible role for growth factors in recovery and continued maintenance of surviving neurons within limbic seizure foci.

Original languageEnglish (US)
Pages (from-to)1445-1449
Number of pages5
Issue number6
StatePublished - Jan 1 1997


  • Brain-derived nerve factor (BDNF)
  • Hippocampus
  • Kainic acid
  • Neurotrophin 3 (NT3)
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)


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