Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains.

Marjorie U. Yang, Anna N. Yaroslavsky, William A. Farinelli, Thomas J. Flotte, Francisca Rius-Diaz, Sandy S. Tsao, R. Rox Anderson

Research output: Contribution to journalArticle

122 Scopus citations


OBJECTIVE: Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength. METHODS: PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose (MPD) were used for Nd:YAG laser. Posttreatment biopsy specimens were taken. Blind assessment and quantitative analysis of PWS clearing were performed from digital photographs. RESULTS: MPD for Nd:YAG laser varied widely, from 40 to 250 J/cm 2 . Purpura lasted longer after PDL. Treatment achieved similar 50% to 75% clearing with both PDL and Nd:YAG laser at 1 MPD. Nd:YAG caused greater perivascular and epidermal injury. Scarring occurred in the only patient treated with a Nd:YAG fluence greater than 1 MPD. Patients preferred Nd:YAG laser because of their faster recovery. CONCLUSION: Nd:YAG laser used at MPD is as effective as PDL for treating PWS. Nd:YAG laser fluences higher than MPD may cause scarring.

Original languageEnglish (US)
Pages (from-to)480-490
Number of pages11
JournalJournal of the American Academy of Dermatology
Issue number3 Pt 1
StatePublished - Mar 2005


ASJC Scopus subject areas

  • Dermatology

Cite this

Yang, M. U., Yaroslavsky, A. N., Farinelli, W. A., Flotte, T. J., Rius-Diaz, F., Tsao, S. S., & Anderson, R. R. (2005). Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains. Journal of the American Academy of Dermatology, 52(3 Pt 1), 480-490.