TY - JOUR
T1 - Long noncoding RNAs during normal and malignant hematopoiesis
AU - Alvarez-Dominguez, Juan R.
AU - Hu, Wenqian
AU - Gromatzky, Austin A.
AU - Lodish, Harvey F.
PY - 2014/5
Y1 - 2014/5
N2 - Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncRNAs. Many of these noncoding genes and their targets become dysregulated during malignant hematopoiesis, directly implicating lncRNAs in blood cancers such as leukemia. In a few cases, dysregulation of an lncRNA alone leads to malignant hematopoiesis in a mouse model. Thus, lncRNAs may be not only useful as markers for the diagnosis and prognosis of cancers of the blood, but also as potential targets for novel therapies.
AB - Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncRNAs. Many of these noncoding genes and their targets become dysregulated during malignant hematopoiesis, directly implicating lncRNAs in blood cancers such as leukemia. In a few cases, dysregulation of an lncRNA alone leads to malignant hematopoiesis in a mouse model. Thus, lncRNAs may be not only useful as markers for the diagnosis and prognosis of cancers of the blood, but also as potential targets for novel therapies.
KW - Hematopoiesis
KW - Leukemia
KW - Long noncoding RNAs (lncRNAs)
UR - http://www.scopus.com/inward/record.url?scp=84901593069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901593069&partnerID=8YFLogxK
U2 - 10.1007/s12185-014-1552-8
DO - 10.1007/s12185-014-1552-8
M3 - Review article
C2 - 24609766
AN - SCOPUS:84901593069
SN - 0925-5710
VL - 99
SP - 531
EP - 541
JO - International journal of hematology
JF - International journal of hematology
IS - 5
ER -