Long noncoding RNAs during normal and malignant hematopoiesis

Juan R. Alvarez-Dominguez, Wenqian Hu, Austin A. Gromatzky, Harvey F. Lodish

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncRNAs. Many of these noncoding genes and their targets become dysregulated during malignant hematopoiesis, directly implicating lncRNAs in blood cancers such as leukemia. In a few cases, dysregulation of an lncRNA alone leads to malignant hematopoiesis in a mouse model. Thus, lncRNAs may be not only useful as markers for the diagnosis and prognosis of cancers of the blood, but also as potential targets for novel therapies.

Original languageEnglish (US)
Pages (from-to)531-541
Number of pages11
JournalInternational journal of hematology
Volume99
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Hematopoiesis
  • Leukemia
  • Long noncoding RNAs (lncRNAs)

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Long noncoding RNAs during normal and malignant hematopoiesis'. Together they form a unique fingerprint.

Cite this