Abstract
Long noncoding RNAs (lncRNAs) are differentially expressed under both normal and pathological conditions, implying that they may play important biological functions. Here we examined the expression of lncRNAs during erythropoiesis and identified an erythroid-specific lncRNA with anti-apoptotic activity. Inhibition of this lncRNA blocks erythroid differentiation and promotes apoptosis. Conversely, ectopic expression of this lncRNA can inhibit apoptosis in mouse erythroid cells. This lncRNA represses expression of Pycard, a proapoptotic gene, explaining in part the inhibition of programmed cell death. These findings reveal a novel layer of regulation of cell differentiation and apoptosis by a lncRNA.
Original language | English (US) |
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Pages (from-to) | 2573-2578 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 25 |
Issue number | 24 |
DOIs | |
State | Published - Dec 15 2011 |
Keywords
- Apoptosis
- Erythroid terminal differentiation
- Long noncoding RNA
ASJC Scopus subject areas
- Genetics
- Developmental Biology