Long noncoding and circular RNAs in lung cancer: Advances and perspectives

Weijia Xie, Shuai Yuan, Zhifu D Sun, Yafei Li

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Better understanding and management of lung cancer are needed. Although much has been learned from known protein coding genes, long noncoding RNAs (lncRNAs), a relatively new and fast evolving large family of transcripts, have recently generated much attention for new discoveries. LncRNAs play critical regulatory functions and are emerging as new players in tumorigenesis and phenotypic determinators of lung cancer. In this review, we highlight the latest development of lncRNAs, including circular RNAs in lung cancer. We start with well-characterized lncRNAs and circular RNAs as an oncogene or tumor suppressor and then extend our discussion on the impact of SNPs in lncRNA on its functions and lung cancer risk and the clinical applications of lncRNAs as biomarkers and therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1275-1287
Number of pages13
JournalEpigenomics
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • biomarkers
  • circular RNA
  • long noncoding RNA
  • lung cancer
  • oncogenic lncRNA
  • tumor suppressive lncRNA

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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