Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

Mansi A. Parasramka; Tushar Patel

doi:10.3978/j.issn.2306-9759.2016.01.01

Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

Mansi A. Parasramka, Tushar Patel

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention.

Original language	English (US)
Article number	1
Journal	Stem Cell Investigation
Volume	2016
Issue number	JAN
DOIs	https://doi.org/10.3978/j.issn.2306-9759.2016.01.01
State	Published - Jan 1 2016

Keywords

Cancer stem cells (CSC)
Hepatocellular carcinoma (HCC)
Long non-coding RNAs (lncRNA)

ASJC Scopus subject areas

Molecular Biology
Genetics
Developmental Biology
Cell Biology

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10.3978/j.issn.2306-9759.2016.01.01

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title = "Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities",

abstract = "Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention.",

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AU - Patel, Tushar

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N2 - Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention.

AB - Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention.

KW - Cancer stem cells (CSC)

KW - Hepatocellular carcinoma (HCC)

KW - Long non-coding RNAs (lncRNA)

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DO - 10.3978/j.issn.2306-9759.2016.01.01

M3 - Review article

AN - SCOPUS:84994852257

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JO - Stem Cell Investigation

JF - Stem Cell Investigation

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Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

Abstract

Keywords

ASJC Scopus subject areas

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