Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

Mansi A. Parasramka, Tushar C Patel

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention.

Original languageEnglish (US)
Article number1
JournalStem Cell Investigation
Volume2016
Issue numberJAN
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cancer stem cells (CSC)
  • Hepatocellular carcinoma (HCC)
  • Long non-coding RNAs (lncRNA)

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Genetics
  • Developmental Biology

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