Long interspersed element-1 protein expression is a hallmark of many human cancers

Nemanja Rodić, Reema Sharma, Rajni Sharma, John Zampella, Lixin Dai, Martin S. Taylor, Ralph H. Hruban, Christine A. Iacobuzio-Donahue, Anirban Maitra, Michael Torbenson, Michael Goggins, Ie Ming Shih, Amy S. Duffield, Elizabeth A. Montgomery, Edward Gabrielson, George J. Netto, Tamara L. Lotan, Angelo M. De Marzo, William Westra, Zev A. BinderBrent A. Orr, Gary L. Gallia, Charles G. Eberhart, Jef D. Boeke, Chris R. Harris, Kathleen H. Burns

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Cancers comprise a heterogeneous group of human diseases. Unifying characteristics include unchecked abilities of tumor cells to proliferate and spread anatomically, and the presence of clonal advantageous genetic changes. However, universal and highly specific tumor markers are unknown. Herein, we report widespread long interspersed element-1 (LINE-1) repeat expression in human cancers. We show that nearly half of all human cancers are immunoreactive for a LINE-1-encoded protein. LINE-1 protein expression is a common feature of many types of high-grade malignant cancers, is rarely detected in early stages of tumorigenesis, and is absent from normal somatic tissues. Studies have shown that LINE-1 contributes to genetic changes in cancers, with somatic LINE-1 insertions seen in selected types of human cancers, particularly colon cancer. We sought to correlate this observation with expression of the LINE-1-encoded protein, open reading frame 1 protein, and found that LINE-1 open reading frame 1 protein is a surprisingly broad, yet highly tumor-specific, antigen.

Original languageEnglish (US)
Pages (from-to)1280-1286
Number of pages7
JournalAmerican Journal of Pathology
Volume184
Issue number5
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Neoplasms
Proteins
Colonic Neoplasms
Open Reading Frames
Neoplasm Antigens
Tumor Biomarkers
Carcinogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Rodić, N., Sharma, R., Sharma, R., Zampella, J., Dai, L., Taylor, M. S., ... Burns, K. H. (2014). Long interspersed element-1 protein expression is a hallmark of many human cancers. American Journal of Pathology, 184(5), 1280-1286. https://doi.org/10.1016/j.ajpath.2014.01.007

Long interspersed element-1 protein expression is a hallmark of many human cancers. / Rodić, Nemanja; Sharma, Reema; Sharma, Rajni; Zampella, John; Dai, Lixin; Taylor, Martin S.; Hruban, Ralph H.; Iacobuzio-Donahue, Christine A.; Maitra, Anirban; Torbenson, Michael; Goggins, Michael; Shih, Ie Ming; Duffield, Amy S.; Montgomery, Elizabeth A.; Gabrielson, Edward; Netto, George J.; Lotan, Tamara L.; De Marzo, Angelo M.; Westra, William; Binder, Zev A.; Orr, Brent A.; Gallia, Gary L.; Eberhart, Charles G.; Boeke, Jef D.; Harris, Chris R.; Burns, Kathleen H.

In: American Journal of Pathology, Vol. 184, No. 5, 01.01.2014, p. 1280-1286.

Research output: Contribution to journalArticle

Rodić, N, Sharma, R, Sharma, R, Zampella, J, Dai, L, Taylor, MS, Hruban, RH, Iacobuzio-Donahue, CA, Maitra, A, Torbenson, M, Goggins, M, Shih, IM, Duffield, AS, Montgomery, EA, Gabrielson, E, Netto, GJ, Lotan, TL, De Marzo, AM, Westra, W, Binder, ZA, Orr, BA, Gallia, GL, Eberhart, CG, Boeke, JD, Harris, CR & Burns, KH 2014, 'Long interspersed element-1 protein expression is a hallmark of many human cancers', American Journal of Pathology, vol. 184, no. 5, pp. 1280-1286. https://doi.org/10.1016/j.ajpath.2014.01.007
Rodić, Nemanja ; Sharma, Reema ; Sharma, Rajni ; Zampella, John ; Dai, Lixin ; Taylor, Martin S. ; Hruban, Ralph H. ; Iacobuzio-Donahue, Christine A. ; Maitra, Anirban ; Torbenson, Michael ; Goggins, Michael ; Shih, Ie Ming ; Duffield, Amy S. ; Montgomery, Elizabeth A. ; Gabrielson, Edward ; Netto, George J. ; Lotan, Tamara L. ; De Marzo, Angelo M. ; Westra, William ; Binder, Zev A. ; Orr, Brent A. ; Gallia, Gary L. ; Eberhart, Charles G. ; Boeke, Jef D. ; Harris, Chris R. ; Burns, Kathleen H. / Long interspersed element-1 protein expression is a hallmark of many human cancers. In: American Journal of Pathology. 2014 ; Vol. 184, No. 5. pp. 1280-1286.
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