Locked-in syndrome due to invasive fungal rhinosinusitis in an immunosuppressed patient

Nathan P. Young, P. James B. Dyck, Eelco F.M. Wijdicks

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

BACKGROUND: The locked-in syndrome is typically caused by basilar artery thrombosis, resulting in ventral pontine infarction. Infectious basilar arteritis is a rare alternative etiology. CASE SUMMARY: We present a 24-year-old female with a prodrome of facial pain without fever or meningismus, who developed a locked-in syndrome due to an invasive fungal infection after bone marrow transplantation. The clinical course and neuroimaging demonstrating sinusitis with adjacent pontine infarction but without basilar artery thrombosis are presented. The infectious differential diagnosis and management of invasive fungal infection are discussed. CONCLUSION: Facial pain without fever or meningismus may be an early symptom of invasive fungal rhinosinusitis, which may involve small basilar pontine perforating arteries, leading to a locked-in syndrome in immunosuppressed patients. Early recognition and treatment may prevent life-threatening neurologic complications.

Original languageEnglish (US)
Pages (from-to)158-160
Number of pages3
JournalNeurologist
Volume13
Issue number3
DOIs
StatePublished - May 1 2007

Keywords

  • Invasive fungal rhinosinusitis
  • Locked-in syndrome

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Locked-in syndrome due to invasive fungal rhinosinusitis in an immunosuppressed patient'. Together they form a unique fingerprint.

Cite this