Locally invasive papillary thyroid carcinoma: 1940-1990

T. V. McCaffrey, E. J. Bergstralh, Ian D Hay

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Well-differentiated thyroid carcinoma infrequently invades the upper aerodigestive tract. However, when invasion occurs, it is the source of significant morbidity. The most common structures invaded by thyroid carcinoma are the recurrent laryngeal nerves, larynx, pharynx, and esophagus. Invasion of these structures produces symptoms of airway insufficiency, dysphagia, and hemoptysis. This study was designed to define more clearly the significance of invasion of papillary thyroid carcinoma on survival. At the Mayo Clinic, 262 patients treated for invasive papillary thyroid carcinoma between 1940 and 1990 were retrospectively evaluated. In this group the sites of invasion were muscle 53%, trachea 37%, laryngeal nerve 47%, esophagus 21%, larynx 12%, and other sites 30%. Complete tumor removal was accomplished in 56% of cases. Kaplan-Meier survival curves were calculated for the population. The overall survival was 79% at 5 years, 63% at 10 years, and 54% at 15 years. When the Cox proportional hazard model was applied to the survival data, the factors that had significant influence on survival were invasion of the trachea and the esophagus. Completeness of resection approached statistical significance. Muscle invasion, laryngeal invasion, and recurrent laryngeal nerve invasion had no significant independent influence on survival. These data suggest that when papillary thyroid carcinoma extends beyond the thyroid capsule and invades adjacent structures, the site invaded will influence survival. Survival may be improved in those cases in which complete surgical excision of the tumor is performed.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalHead and Neck
Volume16
Issue number2
StatePublished - 1994

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Survival
Esophagus
Recurrent Laryngeal Nerve
Larynx
Trachea
Thyroid Neoplasms
Laryngeal Nerves
Laryngeal Muscles
Hemoptysis
Kaplan-Meier Estimate
Deglutition Disorders
Pharynx
Papillary Thyroid cancer
Proportional Hazards Models
Capsules
Neoplasms
Thyroid Gland
Morbidity
Muscles
Population

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

McCaffrey, T. V., Bergstralh, E. J., & Hay, I. D. (1994). Locally invasive papillary thyroid carcinoma: 1940-1990. Head and Neck, 16(2), 165-172.

Locally invasive papillary thyroid carcinoma : 1940-1990. / McCaffrey, T. V.; Bergstralh, E. J.; Hay, Ian D.

In: Head and Neck, Vol. 16, No. 2, 1994, p. 165-172.

Research output: Contribution to journalArticle

McCaffrey, TV, Bergstralh, EJ & Hay, ID 1994, 'Locally invasive papillary thyroid carcinoma: 1940-1990', Head and Neck, vol. 16, no. 2, pp. 165-172.
McCaffrey TV, Bergstralh EJ, Hay ID. Locally invasive papillary thyroid carcinoma: 1940-1990. Head and Neck. 1994;16(2):165-172.
McCaffrey, T. V. ; Bergstralh, E. J. ; Hay, Ian D. / Locally invasive papillary thyroid carcinoma : 1940-1990. In: Head and Neck. 1994 ; Vol. 16, No. 2. pp. 165-172.
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