Localized vasculitis of the gastrointestinal tract: A case series

Carlo Salvarani, Kenneth T. Calamia, Cynthia Crowson, Dylan V. Miller, Aaron W. Broadwell, Gene G. Hunder, Eric Lawrence Matteson, Kenneth J Warrington

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective. To describe the clinical features and outcomes of patients with localized vasculitis of the gastrointestinal tract (LVGT). Methods. Medical records of 608 patients diagnosed with vasculitis involving the intra-abdominal vasculature and/or abdominal viscera between January 1996 and December 2007 were reviewed. Only patients with histopathological confirmation or typical angiographic findings of vasculitis localized to the abdomen were included. Results. We identified 18 cases with LVGT over the 12-year study period. The patients were predominantly Caucasian (89%) and female (67%) with a median age at diagnosis of 53.5 (range 17.4-83.3) years. Most of the patients presented with abdominal pain and 12 (66.6%) patients presented with an acute abdomen requiring surgical intervention. At diagnosis, the median ESR was 30.5 (range 4-77) mm/h. Autoantibody screening was generally unrevealing. Abdominal CT scan findings included: bowel wall thickening, bowel infarction and solid organ infarcts. In 14 patients, the diagnosis of vasculitis was established by abdominal angiography. Histological evidence of vasculitis was recorded in 5 (28%) patients, most commonly from gall bladder or small intestine specimens. Corticosteroid therapy was administered to 10 (56%) patients, 5 of whom also received other immunosuppressive agents. Median duration of follow-up was 10.5 (range 2-156) months. No evidence of vasculitis outside the abdomen was observed during follow-up. Seven (39%) patients died during the follow-up period. Survival of the patient cohort (compared with an age-matched US white population) was significantly reduced (P <0.001). Conclusion. LVGT is an uncommon form of vasculitis that can be associated with significant morbidity and mortality.

Original languageEnglish (US)
Article numberkeq093
Pages (from-to)1326-1335
Number of pages10
JournalRheumatology
Volume49
Issue number7
DOIs
StatePublished - Apr 1 2010

Fingerprint

Vasculitis
Gastrointestinal Tract
Abdomen
Acute Abdomen
Viscera
Immunosuppressive Agents
Autoantibodies
Infarction
Abdominal Pain
Small Intestine
Medical Records
Angiography
Adrenal Cortex Hormones
Urinary Bladder
Morbidity
Survival
Mortality

Keywords

  • Abdominal pain
  • Case series
  • Colon
  • Corticosteroids
  • Gall bladder
  • Gastrointestinal tract
  • Immunosuppressive therapy
  • Mesenteric ischaemia
  • Small intestine
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Salvarani, C., Calamia, K. T., Crowson, C., Miller, D. V., Broadwell, A. W., Hunder, G. G., ... Warrington, K. J. (2010). Localized vasculitis of the gastrointestinal tract: A case series. Rheumatology, 49(7), 1326-1335. [keq093]. https://doi.org/10.1093/rheumatology/keq093

Localized vasculitis of the gastrointestinal tract : A case series. / Salvarani, Carlo; Calamia, Kenneth T.; Crowson, Cynthia; Miller, Dylan V.; Broadwell, Aaron W.; Hunder, Gene G.; Matteson, Eric Lawrence; Warrington, Kenneth J.

In: Rheumatology, Vol. 49, No. 7, keq093, 01.04.2010, p. 1326-1335.

Research output: Contribution to journalArticle

Salvarani, C, Calamia, KT, Crowson, C, Miller, DV, Broadwell, AW, Hunder, GG, Matteson, EL & Warrington, KJ 2010, 'Localized vasculitis of the gastrointestinal tract: A case series', Rheumatology, vol. 49, no. 7, keq093, pp. 1326-1335. https://doi.org/10.1093/rheumatology/keq093
Salvarani C, Calamia KT, Crowson C, Miller DV, Broadwell AW, Hunder GG et al. Localized vasculitis of the gastrointestinal tract: A case series. Rheumatology. 2010 Apr 1;49(7):1326-1335. keq093. https://doi.org/10.1093/rheumatology/keq093
Salvarani, Carlo ; Calamia, Kenneth T. ; Crowson, Cynthia ; Miller, Dylan V. ; Broadwell, Aaron W. ; Hunder, Gene G. ; Matteson, Eric Lawrence ; Warrington, Kenneth J. / Localized vasculitis of the gastrointestinal tract : A case series. In: Rheumatology. 2010 ; Vol. 49, No. 7. pp. 1326-1335.
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abstract = "Objective. To describe the clinical features and outcomes of patients with localized vasculitis of the gastrointestinal tract (LVGT). Methods. Medical records of 608 patients diagnosed with vasculitis involving the intra-abdominal vasculature and/or abdominal viscera between January 1996 and December 2007 were reviewed. Only patients with histopathological confirmation or typical angiographic findings of vasculitis localized to the abdomen were included. Results. We identified 18 cases with LVGT over the 12-year study period. The patients were predominantly Caucasian (89{\%}) and female (67{\%}) with a median age at diagnosis of 53.5 (range 17.4-83.3) years. Most of the patients presented with abdominal pain and 12 (66.6{\%}) patients presented with an acute abdomen requiring surgical intervention. At diagnosis, the median ESR was 30.5 (range 4-77) mm/h. Autoantibody screening was generally unrevealing. Abdominal CT scan findings included: bowel wall thickening, bowel infarction and solid organ infarcts. In 14 patients, the diagnosis of vasculitis was established by abdominal angiography. Histological evidence of vasculitis was recorded in 5 (28{\%}) patients, most commonly from gall bladder or small intestine specimens. Corticosteroid therapy was administered to 10 (56{\%}) patients, 5 of whom also received other immunosuppressive agents. Median duration of follow-up was 10.5 (range 2-156) months. No evidence of vasculitis outside the abdomen was observed during follow-up. Seven (39{\%}) patients died during the follow-up period. Survival of the patient cohort (compared with an age-matched US white population) was significantly reduced (P <0.001). Conclusion. LVGT is an uncommon form of vasculitis that can be associated with significant morbidity and mortality.",
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AU - Salvarani, Carlo

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N2 - Objective. To describe the clinical features and outcomes of patients with localized vasculitis of the gastrointestinal tract (LVGT). Methods. Medical records of 608 patients diagnosed with vasculitis involving the intra-abdominal vasculature and/or abdominal viscera between January 1996 and December 2007 were reviewed. Only patients with histopathological confirmation or typical angiographic findings of vasculitis localized to the abdomen were included. Results. We identified 18 cases with LVGT over the 12-year study period. The patients were predominantly Caucasian (89%) and female (67%) with a median age at diagnosis of 53.5 (range 17.4-83.3) years. Most of the patients presented with abdominal pain and 12 (66.6%) patients presented with an acute abdomen requiring surgical intervention. At diagnosis, the median ESR was 30.5 (range 4-77) mm/h. Autoantibody screening was generally unrevealing. Abdominal CT scan findings included: bowel wall thickening, bowel infarction and solid organ infarcts. In 14 patients, the diagnosis of vasculitis was established by abdominal angiography. Histological evidence of vasculitis was recorded in 5 (28%) patients, most commonly from gall bladder or small intestine specimens. Corticosteroid therapy was administered to 10 (56%) patients, 5 of whom also received other immunosuppressive agents. Median duration of follow-up was 10.5 (range 2-156) months. No evidence of vasculitis outside the abdomen was observed during follow-up. Seven (39%) patients died during the follow-up period. Survival of the patient cohort (compared with an age-matched US white population) was significantly reduced (P <0.001). Conclusion. LVGT is an uncommon form of vasculitis that can be associated with significant morbidity and mortality.

AB - Objective. To describe the clinical features and outcomes of patients with localized vasculitis of the gastrointestinal tract (LVGT). Methods. Medical records of 608 patients diagnosed with vasculitis involving the intra-abdominal vasculature and/or abdominal viscera between January 1996 and December 2007 were reviewed. Only patients with histopathological confirmation or typical angiographic findings of vasculitis localized to the abdomen were included. Results. We identified 18 cases with LVGT over the 12-year study period. The patients were predominantly Caucasian (89%) and female (67%) with a median age at diagnosis of 53.5 (range 17.4-83.3) years. Most of the patients presented with abdominal pain and 12 (66.6%) patients presented with an acute abdomen requiring surgical intervention. At diagnosis, the median ESR was 30.5 (range 4-77) mm/h. Autoantibody screening was generally unrevealing. Abdominal CT scan findings included: bowel wall thickening, bowel infarction and solid organ infarcts. In 14 patients, the diagnosis of vasculitis was established by abdominal angiography. Histological evidence of vasculitis was recorded in 5 (28%) patients, most commonly from gall bladder or small intestine specimens. Corticosteroid therapy was administered to 10 (56%) patients, 5 of whom also received other immunosuppressive agents. Median duration of follow-up was 10.5 (range 2-156) months. No evidence of vasculitis outside the abdomen was observed during follow-up. Seven (39%) patients died during the follow-up period. Survival of the patient cohort (compared with an age-matched US white population) was significantly reduced (P <0.001). Conclusion. LVGT is an uncommon form of vasculitis that can be associated with significant morbidity and mortality.

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KW - Small intestine

KW - Vasculitis

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