TY - JOUR
T1 - Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve
AU - Roumy, Aurélien
AU - De Leval, Laurence
AU - Niclauss, Lars
AU - Schaefer, Stephan C.
AU - Kurtin, Paul
AU - Dogan, Ahmet
AU - Von Segesser, Ludwig K.
AU - Ruchat, Patrick
PY - 2013/5
Y1 - 2013/5
N2 - An unusual case of localized amyloid light-chain (AL) amyloidosis and extramedullary plasmacytoma of the mitral valve is described. The worsening of a mitral regurgitation led to investigations and surgery. The valve presented marked distortion and thickening by type AL amyloid associated with a monotypic CD138+ immunoglobulin lambda plasma cell proliferation. Systemic staging showed a normal bone marrow and no evidence of amyloid deposition in other localizations. The patient's outcome after mitral valve replacement was excellent. To our knowledge, this is the first description of a localized AL amyloidosis as well as of a primary extramedullary plasmacytoma of the mitral valve.
AB - An unusual case of localized amyloid light-chain (AL) amyloidosis and extramedullary plasmacytoma of the mitral valve is described. The worsening of a mitral regurgitation led to investigations and surgery. The valve presented marked distortion and thickening by type AL amyloid associated with a monotypic CD138+ immunoglobulin lambda plasma cell proliferation. Systemic staging showed a normal bone marrow and no evidence of amyloid deposition in other localizations. The patient's outcome after mitral valve replacement was excellent. To our knowledge, this is the first description of a localized AL amyloidosis as well as of a primary extramedullary plasmacytoma of the mitral valve.
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U2 - 10.1016/j.athoracsur.2012.08.085
DO - 10.1016/j.athoracsur.2012.08.085
M3 - Article
C2 - 23608260
AN - SCOPUS:84876570799
VL - 95
SP - 1782
EP - 1784
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 5
ER -