Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve

Aurélien Roumy, Laurence De Leval, Lars Niclauss, Stephan C. Schaefer, Paul Kurtin, Ahmet Dogan, Ludwig K. Von Segesser, Patrick Ruchat

Research output: Contribution to journalArticle

Abstract

An unusual case of localized amyloid light-chain (AL) amyloidosis and extramedullary plasmacytoma of the mitral valve is described. The worsening of a mitral regurgitation led to investigations and surgery. The valve presented marked distortion and thickening by type AL amyloid associated with a monotypic CD138+ immunoglobulin lambda plasma cell proliferation. Systemic staging showed a normal bone marrow and no evidence of amyloid deposition in other localizations. The patient's outcome after mitral valve replacement was excellent. To our knowledge, this is the first description of a localized AL amyloidosis as well as of a primary extramedullary plasmacytoma of the mitral valve.

Original languageEnglish (US)
Pages (from-to)1782-1784
Number of pages3
JournalAnnals of Thoracic Surgery
Volume95
Issue number5
DOIs
StatePublished - May 2013

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Roumy, A., De Leval, L., Niclauss, L., Schaefer, S. C., Kurtin, P., Dogan, A., Von Segesser, L. K., & Ruchat, P. (2013). Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve. Annals of Thoracic Surgery, 95(5), 1782-1784. https://doi.org/10.1016/j.athoracsur.2012.08.085