Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3

M. W. Berchtold, R. Egli, J. A. Rhyner, H. Hameister, E. E. Strehler

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA from human-hamster cell hybrids as template. Employing calmodulin gene-specific DNA probes of mainly intronic or flanking parts of the individual genes, regional sub-localization was performed by in situ hybridization on metaphase spreads of human lymphocytes. The three calmodulin genes map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively. These results represent the first complete chromosomal localization study on a mammalian calmodulin gene family and indicate that these structurally closely related genes were most likely dispersed throughout the genome concomitantly with their generation from an ancestral precursor gene.

Original languageEnglish (US)
Pages (from-to)461-465
Number of pages5
JournalGenomics
Volume16
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Calmodulin
Chromosomes
Genes
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 2
Hybrid Cells
Gene Amplification
DNA Probes
Human Chromosomes
Metaphase
Cricetinae
In Situ Hybridization
Genome
Lymphocytes
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Genetics

Cite this

Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. / Berchtold, M. W.; Egli, R.; Rhyner, J. A.; Hameister, H.; Strehler, E. E.

In: Genomics, Vol. 16, No. 2, 1993, p. 461-465.

Research output: Contribution to journalArticle

Berchtold, M. W. ; Egli, R. ; Rhyner, J. A. ; Hameister, H. ; Strehler, E. E. / Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. In: Genomics. 1993 ; Vol. 16, No. 2. pp. 461-465.
@article{c1f667b1b41c4063a14711dcd53d5638,
title = "Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3",
abstract = "The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA from human-hamster cell hybrids as template. Employing calmodulin gene-specific DNA probes of mainly intronic or flanking parts of the individual genes, regional sub-localization was performed by in situ hybridization on metaphase spreads of human lymphocytes. The three calmodulin genes map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively. These results represent the first complete chromosomal localization study on a mammalian calmodulin gene family and indicate that these structurally closely related genes were most likely dispersed throughout the genome concomitantly with their generation from an ancestral precursor gene.",
author = "Berchtold, {M. W.} and R. Egli and Rhyner, {J. A.} and H. Hameister and Strehler, {E. E.}",
year = "1993",
doi = "10.1006/geno.1993.1211",
language = "English (US)",
volume = "16",
pages = "461--465",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3

AU - Berchtold, M. W.

AU - Egli, R.

AU - Rhyner, J. A.

AU - Hameister, H.

AU - Strehler, E. E.

PY - 1993

Y1 - 1993

N2 - The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA from human-hamster cell hybrids as template. Employing calmodulin gene-specific DNA probes of mainly intronic or flanking parts of the individual genes, regional sub-localization was performed by in situ hybridization on metaphase spreads of human lymphocytes. The three calmodulin genes map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively. These results represent the first complete chromosomal localization study on a mammalian calmodulin gene family and indicate that these structurally closely related genes were most likely dispersed throughout the genome concomitantly with their generation from an ancestral precursor gene.

AB - The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA from human-hamster cell hybrids as template. Employing calmodulin gene-specific DNA probes of mainly intronic or flanking parts of the individual genes, regional sub-localization was performed by in situ hybridization on metaphase spreads of human lymphocytes. The three calmodulin genes map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively. These results represent the first complete chromosomal localization study on a mammalian calmodulin gene family and indicate that these structurally closely related genes were most likely dispersed throughout the genome concomitantly with their generation from an ancestral precursor gene.

UR - http://www.scopus.com/inward/record.url?scp=0027207975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027207975&partnerID=8YFLogxK

U2 - 10.1006/geno.1993.1211

DO - 10.1006/geno.1993.1211

M3 - Article

C2 - 8314583

AN - SCOPUS:0027207975

VL - 16

SP - 461

EP - 465

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -