We used probes for DNA polymorphism on the X chromosome to study genetic linkage in seven families with X-linked adult-onset spinal muscular atrophy. We found significant linkage to the marker DXYS1 on the proximal X chromosome long arm and loose linkage or nonlinkage to markers elsewhere. Our analysis localizes the gene defect for this form of anterior horn cell disease.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Dec 1986|
ASJC Scopus subject areas
- Clinical Neurology