Localization of the gene for X-linked spinal muscular atrophy

K. H. Fischbeck, V. Ionasescu, A. W. Ritter, K. Davies, S. Ball, P. Bosch, T. Burns, I. Hausmanowa-Petrusewicz, J. Borkowska

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in seven families with X-linked adult-onset spinal muscular atrophy. We found significant linkage to the marker DXYS1 on the proximal X chromosome long arm and loose linkage or nonlinkage to markers elsewhere. Our analysis localizes the gene defect for this form of anterior horn cell disease.

Original languageEnglish (US)
Pages (from-to)1595-1598
Number of pages4
JournalNeurology
Volume36
Issue number12
StatePublished - 1986
Externally publishedYes

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Spinal Muscular Atrophy
X-Linked Genes
X Chromosome
Motor Neuron Disease
Genetic Linkage
DNA Probes
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fischbeck, K. H., Ionasescu, V., Ritter, A. W., Davies, K., Ball, S., Bosch, P., ... Borkowska, J. (1986). Localization of the gene for X-linked spinal muscular atrophy. Neurology, 36(12), 1595-1598.

Localization of the gene for X-linked spinal muscular atrophy. / Fischbeck, K. H.; Ionasescu, V.; Ritter, A. W.; Davies, K.; Ball, S.; Bosch, P.; Burns, T.; Hausmanowa-Petrusewicz, I.; Borkowska, J.

In: Neurology, Vol. 36, No. 12, 1986, p. 1595-1598.

Research output: Contribution to journalArticle

Fischbeck, KH, Ionasescu, V, Ritter, AW, Davies, K, Ball, S, Bosch, P, Burns, T, Hausmanowa-Petrusewicz, I & Borkowska, J 1986, 'Localization of the gene for X-linked spinal muscular atrophy', Neurology, vol. 36, no. 12, pp. 1595-1598.
Fischbeck KH, Ionasescu V, Ritter AW, Davies K, Ball S, Bosch P et al. Localization of the gene for X-linked spinal muscular atrophy. Neurology. 1986;36(12):1595-1598.
Fischbeck, K. H. ; Ionasescu, V. ; Ritter, A. W. ; Davies, K. ; Ball, S. ; Bosch, P. ; Burns, T. ; Hausmanowa-Petrusewicz, I. ; Borkowska, J. / Localization of the gene for X-linked spinal muscular atrophy. In: Neurology. 1986 ; Vol. 36, No. 12. pp. 1595-1598.
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