Abstract
We used probes for DNA polymorphism on the X chromosome to study genetic linkage in seven families with X-linked adult-onset spinal muscular atrophy. We found significant linkage to the marker DXYS1 on the proximal X chromosome long arm and loose linkage or nonlinkage to markers elsewhere. Our analysis localizes the gene defect for this form of anterior horn cell disease.
Original language | English (US) |
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Pages (from-to) | 1595-1598 |
Number of pages | 4 |
Journal | Neurology |
Volume | 36 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1986 |
ASJC Scopus subject areas
- Clinical Neurology