TY - JOUR
T1 - Localization of microglia in the human fetal cervical spinal cord
AU - Hutchins, Kenneth D.
AU - Dickson, Dennis W.
AU - Rashbaum, William K.
AU - Lyman, William D.
N1 - Funding Information:
We wish to thank Dr. Linda Mattiace for her kind cooperation and constructive criticism and the very professional and humane nursing staff at the Bronx Municipal Hospital Center (Van Etten and Jacobi Hospitals). The work was supported by UPHS Grants DA 05583, MH 46815, MH 47667, NS 11920 and NS 07098.
PY - 1992/4/24
Y1 - 1992/4/24
N2 - Differential morphologic subtypes of microglia have been identified in the human fetal frontal cerebrum using a lectin, Ricinus communis agglutinin 1 (RCA-1), and a monoclonal antibody, EBM-11. In this report, microglia were characterized in the human fetal cervical spinal cord. RCA-1-positive microglia were ramified in the developing gray matter while in the developing white matter they had a less differentiated (ameboid) appearance. EBM-11, a monoclonal antibody that recognizes CD68 on human macrophages, and microglia labeled only ameboid-type microglia in the developing white matter. This suggests that distinct subpopulations of microglia exist, which may represent different stages in microglial development, and that CD68 may be a differentiation marker for less mature forms. Therefore, cytologically less differentiated forms of microglia appear to be associated with myelination.
AB - Differential morphologic subtypes of microglia have been identified in the human fetal frontal cerebrum using a lectin, Ricinus communis agglutinin 1 (RCA-1), and a monoclonal antibody, EBM-11. In this report, microglia were characterized in the human fetal cervical spinal cord. RCA-1-positive microglia were ramified in the developing gray matter while in the developing white matter they had a less differentiated (ameboid) appearance. EBM-11, a monoclonal antibody that recognizes CD68 on human macrophages, and microglia labeled only ameboid-type microglia in the developing white matter. This suggests that distinct subpopulations of microglia exist, which may represent different stages in microglial development, and that CD68 may be a differentiation marker for less mature forms. Therefore, cytologically less differentiated forms of microglia appear to be associated with myelination.
KW - EBM-11
KW - Human spinal cord
KW - Microglia
KW - RCA-1 lectin
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U2 - 10.1016/0165-3806(92)90091-A
DO - 10.1016/0165-3806(92)90091-A
M3 - Article
C2 - 1606692
AN - SCOPUS:0026529672
SN - 0165-3806
VL - 66
SP - 270
EP - 273
JO - Developmental Brain Research
JF - Developmental Brain Research
IS - 2
ER -