Localization of genes involved in the metabolic syndrome using multivariate linkage analysis.

Curtis Olswold, Mariza de Andrade

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

There are no well accepted criteria for the diagnosis of the metabolic syndrome. However, the metabolic syndrome is identified clinically by the presence of three or more of these five variables: larger waist circumference, higher triglyceride levels, lower HDL-cholesterol concentrations, hypertension, and impaired fasting glucose. We use sets of two or three variables, which are available in the Framingham Heart Study data set, to localize genes responsible for this syndrome using multivariate quantitative linkage analysis. This analysis demonstrates the applicability of using multivariate linkage analysis and how its use increases the power to detect linkage when genes are involved in the same disease mechanism.

Original languageEnglish (US)
JournalBMC genetics
Volume4 Suppl 1
StatePublished - 2003

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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