Local therapies can improve intracerebral control in patients with cerebral metastasis from gynecological cancers

Liesa Dziggel, Stefan Janssen, Amira Bajrovic, Theo Veninga, Ngo Thuy Trang, Mai Trong Khoa, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background/Aim: Patients with gynecological malignancies account for 2% of patients with cerebral metastases. Many patients receive whole-brain irradiation (WBI) alone. Local therapies (resection, stereotactic radiosurgery (SRS)) are becoming more popular. This study compared intracerebral control after local therapy to WBI alone in patients with gynecological malignancies. Patients and Methods: Of 56 patients, 45 received WBI alone, 6 SRS alone and 5 resection plus WBI. Treatment type, age, performance score, cancer site, number of cerebral lesions, metastases outside the brain, recursive partitioning analysis (RPA) class and period from gynecological cancer diagnosis to brain metastasis treatment were evaluated. Results: On univariate analyses, local therapy (p=0.003), single cerebral lesion (p<0.001) and RPA class 1/2 (p=0.027) were positively related to intracerebral control. On Cox regression analysis, local therapy (p=0.013) and RPA class 1/2 (p=0.014) were significant. Conclusion: Local therapies led to better intracerebral control than WBI alone and should be considered for brain metastasis from gynecological malignancies whenever reasonable.

Original languageEnglish (US)
Pages (from-to)4777-4780
Number of pages4
JournalAnticancer research
Volume36
Issue number9
DOIs
StatePublished - Sep 2016

Keywords

  • Cerebral metastasis
  • Gynecological cancers
  • Intracerebral control
  • Neurosurgical resection
  • Stereotactic radiosurgery
  • Whole-brain irradiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Dziggel, L., Janssen, S., Bajrovic, A., Veninga, T., Trang, N. T., Khoa, M. T., Schild, S. E., & Rades, D. (2016). Local therapies can improve intracerebral control in patients with cerebral metastasis from gynecological cancers. Anticancer research, 36(9), 4777-4780. https://doi.org/10.21873/anticanres.11035