Das lokal begrenzte Brustkrebsrezidiv: konventionell fraktionierte partielle perkutane Rebestrahlung in kurativer Intention

Translated title of the contribution: Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention

S. Janssen, D. Rades, A. Meyer, F. B. Fahlbusch, I. Wildfang, A. Meier, S. Schild, H. Christiansen, C. Henkenberens

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Purpose: To assess the outcome of breast cancer patients with local recurrence who underwent partial external beam re-irradiation (re-RT) either as part of a second breast-conserving therapy or following mastectomy. Methods: Between 03/2004 and 10/2016, 83 breast cancer patients with local recurrence were treated with surgery followed by re-RT. The re-RT schedules were 45?Gy (1.8?Gy per fraction) administered either to the partial breast (n?= 42) or mastectomy scar (n?= 41). The patients and tumor characteristics predictive of local control, distant control, and survival (overall and breast-cancer specific) were evaluated by univariate and multivariate analyses. Results: The median follow-up was 35 months (range 3–143 months). The median time interval between the first irradiation and re-RT was 117 months (range 16–357 months). The prognostic factors for favorable overall survival rates were younger age (p?= 0.045), lower T‑category (p?= 0.019), and N0 category (p?= 0.005). N0 was also superior to N+ with respect to outfield recurrences (p?= <0.001) and breast cancer-specific survival (p?= 0.025). Acute and late skin toxicity was generally low (<grade 3). Conclusion: Re-RT with 45?Gy (1.8?Gy per fraction) for partial breast or mastectomy scar after the second surgery resulted in high local control rates and tolerable skin toxicity.

Translated title of the contributionLocal recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention
Original languageGerman
Pages (from-to)1-9
Number of pages9
JournalStrahlentherapie und Onkologie
DOIs
StateAccepted/In press - May 23 2018

Keywords

  • Breast cancer recurrence
  • Breast conserving surgery
  • External beam radiotherapy
  • Mastectomy
  • Partial re-irradiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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    Janssen, S., Rades, D., Meyer, A., Fahlbusch, F. B., Wildfang, I., Meier, A., Schild, S., Christiansen, H., & Henkenberens, C. (Accepted/In press). Das lokal begrenzte Brustkrebsrezidiv: konventionell fraktionierte partielle perkutane Rebestrahlung in kurativer Intention. Strahlentherapie und Onkologie, 1-9. https://doi.org/10.1007/s00066-018-1315-1