Das lokal begrenzte Brustkrebsrezidiv

konventionell fraktionierte partielle perkutane Rebestrahlung in kurativer Intention

Translated title of the contribution: Local recurrence of breast cancer: conventionally fractionated partial external beam re-irradiation with curative intention

S. Janssen, D. Rades, A. Meyer, F. B. Fahlbusch, I. Wildfang, A. Meier, S. Schild, H. Christiansen, C. Henkenberens

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: To assess the outcome of breast cancer patients with local recurrence who underwent partial external beam re-irradiation (re-RT) either as part of a second breast-conserving therapy or following mastectomy. Methods: Between 03/2004 and 10/2016, 83 breast cancer patients with local recurrence were treated with surgery followed by re-RT. The re-RT schedules were 45?Gy (1.8?Gy per fraction) administered either to the partial breast (n?= 42) or mastectomy scar (n?= 41). The patients and tumor characteristics predictive of local control, distant control, and survival (overall and breast-cancer specific) were evaluated by univariate and multivariate analyses. Results: The median follow-up was 35 months (range 3–143 months). The median time interval between the first irradiation and re-RT was 117 months (range 16–357 months). The prognostic factors for favorable overall survival rates were younger age (p?= 0.045), lower T‑category (p?= 0.019), and N0 category (p?= 0.005). N0 was also superior to N+ with respect to outfield recurrences (p?= <0.001) and breast cancer-specific survival (p?= 0.025). Acute and late skin toxicity was generally low (<grade 3). Conclusion: Re-RT with 45?Gy (1.8?Gy per fraction) for partial breast or mastectomy scar after the second surgery resulted in high local control rates and tolerable skin toxicity.

Original languageGerman
Pages (from-to)1-9
Number of pages9
JournalStrahlentherapie und Onkologie
DOIs
StateAccepted/In press - May 23 2018

Fingerprint

Mastectomy
Breast Neoplasms
Recurrence
Breast
Cicatrix
Skin
Survival
Appointments and Schedules
Multivariate Analysis
Survival Rate
Re-Irradiation
Neoplasms
Therapeutics

Keywords

  • Breast cancer recurrence
  • Breast conserving surgery
  • External beam radiotherapy
  • Mastectomy
  • Partial re-irradiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Das lokal begrenzte Brustkrebsrezidiv : konventionell fraktionierte partielle perkutane Rebestrahlung in kurativer Intention. / Janssen, S.; Rades, D.; Meyer, A.; Fahlbusch, F. B.; Wildfang, I.; Meier, A.; Schild, S.; Christiansen, H.; Henkenberens, C.

In: Strahlentherapie und Onkologie, 23.05.2018, p. 1-9.

Research output: Contribution to journalArticle

Janssen, S, Rades, D, Meyer, A, Fahlbusch, FB, Wildfang, I, Meier, A, Schild, S, Christiansen, H & Henkenberens, C 2018, 'Das lokal begrenzte Brustkrebsrezidiv: konventionell fraktionierte partielle perkutane Rebestrahlung in kurativer Intention', Strahlentherapie und Onkologie, pp. 1-9. https://doi.org/10.1007/s00066-018-1315-1
Janssen, S. ; Rades, D. ; Meyer, A. ; Fahlbusch, F. B. ; Wildfang, I. ; Meier, A. ; Schild, S. ; Christiansen, H. ; Henkenberens, C. / Das lokal begrenzte Brustkrebsrezidiv : konventionell fraktionierte partielle perkutane Rebestrahlung in kurativer Intention. In: Strahlentherapie und Onkologie. 2018 ; pp. 1-9.
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