TY - JOUR
T1 - Local Cellular Responses to Titanium Dioxide from Orthopedic Implants
AU - Yao, Jie J.
AU - Lewallen, Eric A.
AU - Trousdale, William H.
AU - Xu, Wei
AU - Thaler, Roman
AU - Salib, Christopher G.
AU - Reina, Nicolas
AU - Abdel, Matthew P.
AU - Lewallen, David G.
AU - Van Wijnen, Andre J.
N1 - Publisher Copyright:
© 2017 Mary Ann Liebert, Inc.
PY - 2017/7
Y1 - 2017/7
N2 - We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO2) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO2 particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain. TiO2 particles that enter cells (through endocytosis or Trojan horse mechanism) may further disrupt implant retention. We propose that cellular responses to titanium-based nanoparticles contribute to pathological mechanisms underlying the aseptic loosening of titanium-based metal implants.
AB - We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO2) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO2 particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain. TiO2 particles that enter cells (through endocytosis or Trojan horse mechanism) may further disrupt implant retention. We propose that cellular responses to titanium-based nanoparticles contribute to pathological mechanisms underlying the aseptic loosening of titanium-based metal implants.
KW - adverse local tissue reaction
KW - joint replacement
KW - nanoparticle
KW - total hip arthroplasty
KW - total knee arthroplasty
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U2 - 10.1089/biores.2017.0017
DO - 10.1089/biores.2017.0017
M3 - Review article
AN - SCOPUS:85025624179
SN - 2164-7860
VL - 6
SP - 94
EP - 103
JO - BioResearch Open Access
JF - BioResearch Open Access
IS - 1
ER -