Local antibiotic delivery with OsteoSet®, DBX®, and Collagraft®

Andras Heijink, Michael J Yaszemski, Robin Patel, Mark S. Rouse, David G. Lewallen, Arlen D. Hanssen

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Biodegradable local antibiotic delivery systems have gained interest for prophylaxis and treatment of musculoskeletal infections. We studied the biodegradable materials Osteo- Set®, DBX® and Collagraft® for local delivery of vancomycin and gentamicin in vitro. We determined the antimicrobial activity of vancomycin and gentamicin after mixing with each biodegradable material and determined the release of each antimicrobial from each material in an intermittent flow chamber. Antimicrobial activity was expressed as percent of antimicrobial loaded into each sample that was detected; antimicrobial release was expressed as concentration (μg/mL) after timed intervals of chamber flow, peak concentration, area under the curve and percent antimicrobial recovered. Activity of vancomycin after mixing with Osteo- Set®, DBX® and Collagraft® was > 73%. Activity of gentamicin after mixing with DBX® was 100%; after mixing with OsteoSet® and Collagraft® it was reduced to < 61%. AUC0-48hrs of vancomycin was 469, 426 and 432 μg × hr/mL, and the AUC0-48hrs of gentamicin was 368, 306 and 301 μg × hr/mL after release from OsteoSet®, DBX®, and Collagraft®, respectively. Recovered percentages of vancomycin were 39%, 11% and 25%, and recovered percentages of gentamicin were 39%, 9% and 23% after release from OsteoSet®, DBX®, and Collagraft®, respectively. OsteoSet®, DBX® and Collagraft® may be suitable for local delivery of vancomycin and gentamicin.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalClinical Orthopaedics and Related Research
Issue number451
DOIs
StatePublished - Oct 2006

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Vancomycin
Gentamicins
Anti-Bacterial Agents
Area Under Curve
Collagraft
Infection

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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Local antibiotic delivery with OsteoSet®, DBX®, and Collagraft®. / Heijink, Andras; Yaszemski, Michael J; Patel, Robin; Rouse, Mark S.; Lewallen, David G.; Hanssen, Arlen D.

In: Clinical Orthopaedics and Related Research, No. 451, 10.2006, p. 29-33.

Research output: Contribution to journalArticle

Heijink, Andras ; Yaszemski, Michael J ; Patel, Robin ; Rouse, Mark S. ; Lewallen, David G. ; Hanssen, Arlen D. / Local antibiotic delivery with OsteoSet®, DBX®, and Collagraft®. In: Clinical Orthopaedics and Related Research. 2006 ; No. 451. pp. 29-33.
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