Abstract
Objectives: The diagnosis of T-lymphoblastic leukemia/lymphoma (T-ALL) involving the thymus can be difficult to establish since neoplastic T lymphoblasts show significant phenotypic overlap with both normal thymocytes and thymocytes from epithelial thymic neoplasms (thymomas). LIMDomain Only 2 (LMO2) gene translocations have been implicated in the pathogenesis of a small subset of T-ALLs, and LMO2 protein has recently been reported to be expressed in a large proportion of T-ALLs. Methods: In this study, we tested specificity of LMO2 for distinction between neoplastic and nonneoplastic T-precursor cells in thymus and bone marrow. Results: Our findings show that LMO2 is expressed in neoplastic lymphoblasts of T-ALL and is absent in thymocytes of normal thymuses or thymomas. Conclusions: LMO2 is therefore a useful marker for immunophenotypic assessment of thymic neoplasms.
Original language | English (US) |
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Pages (from-to) | 180-190 |
Number of pages | 11 |
Journal | American journal of clinical pathology |
Volume | 145 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2016 |
Keywords
- Immunohistochemistry
- LMO2
- T-ALL
ASJC Scopus subject areas
- Pathology and Forensic Medicine