TY - JOUR
T1 - Liver transplantation
T2 - When to say yes or no? Based on a case report
AU - Moreno Gonzales, Manuel
AU - Sanchez, William
AU - Taner, Timucin
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/6
Y1 - 2019/6
N2 - Background: Liver transplantation (LT) is the gold standard therapy for end-stage liver diseases (ESLD) worldwide. Over the past decades, multiple strategies have been developed in order to optimize allograft/recipient outcomes and decrease patient morbidity/mortality. However, maintaining an appropriate balance between “using a limited resource” (i.e. available organs) and “reducing waitlist mortality” arises multiple ethical concerns. Aim: In this report we aimed to address some ethical issues related to a case that occurred in our institution in which liver re-transplantation was performed in a patient with cirrhosis and hepatocellular carcinoma (HCC) as an emergent life-saving therapy. Conclusions: We conclude that expanding the donor pool (e.g. living donor LT, use of extended criteria donors, donation after cardiac death, bridging therapies to delay the necessity of transplantation) is a way to compensate the growing discrepancy between donors and recipients; however, this needs to be evaluated in each individual patient in order to obtain the maximum benefit.
AB - Background: Liver transplantation (LT) is the gold standard therapy for end-stage liver diseases (ESLD) worldwide. Over the past decades, multiple strategies have been developed in order to optimize allograft/recipient outcomes and decrease patient morbidity/mortality. However, maintaining an appropriate balance between “using a limited resource” (i.e. available organs) and “reducing waitlist mortality” arises multiple ethical concerns. Aim: In this report we aimed to address some ethical issues related to a case that occurred in our institution in which liver re-transplantation was performed in a patient with cirrhosis and hepatocellular carcinoma (HCC) as an emergent life-saving therapy. Conclusions: We conclude that expanding the donor pool (e.g. living donor LT, use of extended criteria donors, donation after cardiac death, bridging therapies to delay the necessity of transplantation) is a way to compensate the growing discrepancy between donors and recipients; however, this needs to be evaluated in each individual patient in order to obtain the maximum benefit.
KW - Hepatocellular carcinoma
KW - Liver transplantation
KW - Metastasis
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U2 - 10.1016/j.tpr.2019.100027
DO - 10.1016/j.tpr.2019.100027
M3 - Article
AN - SCOPUS:85064165200
SN - 2451-9596
VL - 4
JO - Transplantation Reports
JF - Transplantation Reports
IS - 2
M1 - 100027
ER -