Liver Transplantation: Indications and Selection of Candidates and Immediate Complications

Patrick S. Kamath; John J. Poterucha

doi:10.1002/9781118321386.ch108

Liver Transplantation: Indications and Selection of Candidates and Immediate Complications

Patrick S. Kamath, John J. Poterucha

Gastroenterology and Hepatology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Liver transplantation is the only established therapy for patients with end-stage liver disease. The procedure is also indicated in fulminant liver failure, metabolic diseases, and hepatocellular carcinoma. Survival after liver transplantation is approximately 75-80% at 3 years. Donor organ shortage is a major limitation in adult liver transplantation and is responsible for significant mortality and morbidity in patients on the waiting list. Strategies to increase the number of donor organs include the use of marginal livers, split liver, and living donors. Life-long immunosuppression is required in these patients. Post-transplant complications include rejection, recurrent disease, opportunistic infections, and lymphoproliferative disorders, in addition to the risk of extrahepatic malignancy.

Original language	English (US)
Title of host publication	Textbook of Clinical Gastroenterology and Hepatology
Subtitle of host publication	Second Edition
Publisher	Wiley-Blackwell
Pages	805-812
Number of pages	8
ISBN (Print)	1405191821, 9781405191821
DOIs	https://doi.org/10.1002/9781118321386.ch108
State	Published - Apr 16 2012

Keywords

Ascites
Child-Turcotte-Pugh
Cirrhosis
Encephalopathy
End-stage liver disease
HCC
Immunosuppression
MELD
Rejection
Variceal bleeding

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1002/9781118321386.ch108

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abstract = "Liver transplantation is the only established therapy for patients with end-stage liver disease. The procedure is also indicated in fulminant liver failure, metabolic diseases, and hepatocellular carcinoma. Survival after liver transplantation is approximately 75-80% at 3 years. Donor organ shortage is a major limitation in adult liver transplantation and is responsible for significant mortality and morbidity in patients on the waiting list. Strategies to increase the number of donor organs include the use of marginal livers, split liver, and living donors. Life-long immunosuppression is required in these patients. Post-transplant complications include rejection, recurrent disease, opportunistic infections, and lymphoproliferative disorders, in addition to the risk of extrahepatic malignancy.",

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N2 - Liver transplantation is the only established therapy for patients with end-stage liver disease. The procedure is also indicated in fulminant liver failure, metabolic diseases, and hepatocellular carcinoma. Survival after liver transplantation is approximately 75-80% at 3 years. Donor organ shortage is a major limitation in adult liver transplantation and is responsible for significant mortality and morbidity in patients on the waiting list. Strategies to increase the number of donor organs include the use of marginal livers, split liver, and living donors. Life-long immunosuppression is required in these patients. Post-transplant complications include rejection, recurrent disease, opportunistic infections, and lymphoproliferative disorders, in addition to the risk of extrahepatic malignancy.

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