Liver Transplantation: Indications and Selection of Candidates and Immediate Complications

Patrick S. Kamath, John J. Poterucha

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Liver transplantation is the only established therapy for patients with end-stage liver disease. The procedure is also indicated in fulminant liver failure, metabolic diseases, and hepatocellular carcinoma. Survival after liver transplantation is approximately 75-80% at 3 years. Donor organ shortage is a major limitation in adult liver transplantation and is responsible for significant mortality and morbidity in patients on the waiting list. Strategies to increase the number of donor organs include the use of marginal livers, split liver, and living donors. Life-long immunosuppression is required in these patients. Post-transplant complications include rejection, recurrent disease, opportunistic infections, and lymphoproliferative disorders, in addition to the risk of extrahepatic malignancy.

Original languageEnglish (US)
Title of host publicationTextbook of Clinical Gastroenterology and Hepatology
Subtitle of host publicationSecond Edition
PublisherWiley-Blackwell
Pages805-812
Number of pages8
ISBN (Print)1405191821, 9781405191821
DOIs
StatePublished - Apr 16 2012

Keywords

  • Ascites
  • Child-Turcotte-Pugh
  • Cirrhosis
  • Encephalopathy
  • End-stage liver disease
  • HCC
  • Immunosuppression
  • MELD
  • Rejection
  • Variceal bleeding

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Kamath, P. S., & Poterucha, J. J. (2012). Liver Transplantation: Indications and Selection of Candidates and Immediate Complications. In Textbook of Clinical Gastroenterology and Hepatology: Second Edition (pp. 805-812). Wiley-Blackwell. https://doi.org/10.1002/9781118321386.ch108