Liver transplantation in the MELD era: A single-center experience

Mankanwal Sachdev, Jose L. Hernandez, Pratima Sharma, David D. Douglas, Thomas Byrne, M. Edwyn Harrison, David Mulligan, Adyr Moss, Kunam Reddy, Hugo E. Vargas, Jorge Rakela, Vijayan Balan

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Model for Endstage Liver Disease (MELD) score has been used to allocate organs since February 2002. This policy allocates organs to candidates with regard to severity of their underlying liver disease except in the case of hepatocellular carcinoma (HCC) patients. The purpose of this study was to determine the impact of MELD on waiting times, dropout rates, and transplantation rates in all patients awaiting liver transplantation at our center. The records of all patients listed for liver transplantation between May 28, 1999, and February 27, 2004, at the Mayo Clinic, Scottsdale, Arizona, were reviewed. Candidates were grouped by two time periods as pre-MELD or post-MELD based on date of MELD implementation (February 27, 2002). The incidence of deceased donor liver transplantation (DDLT), waiting time to DDLT, dropout rate from the waiting list because of clinical deterioration or death, and survival while waiting for or after DDLT were determined for each group. Three hundred fifty-one patients were listed for liver transplantation (195 pre-MELD, 156 post-MELD) during the study period. HCC patients had an improved rate of transplantation after MELD (pre-MELD, 1.39 persons per year; post-MELD, 3.48 persons per year). In all groups, with the exception of hepatitis C virus, the transplantation rates were the same for both categories. The hepatitis C virus group also had improved transplantation rates in the post-MELD period. HCC candidates under the new allocation policy have an increased incidence of DDLT in our institution. However, this has not disadvantaged patients with non-HCC diagnoses. Thus, the new MELD-based allocation policy has benefited all candidates by allowing more timely transplants.

Original languageEnglish (US)
Pages (from-to)1070-1078
Number of pages9
JournalDigestive diseases and sciences
Volume51
Issue number6
DOIs
StatePublished - Jun 1 2006

Keywords

  • Liver
  • Model for Endstage Liver Disease
  • Transplantation

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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    Sachdev, M., Hernandez, J. L., Sharma, P., Douglas, D. D., Byrne, T., Harrison, M. E., Mulligan, D., Moss, A., Reddy, K., Vargas, H. E., Rakela, J., & Balan, V. (2006). Liver transplantation in the MELD era: A single-center experience. Digestive diseases and sciences, 51(6), 1070-1078. https://doi.org/10.1007/s10620-006-8011-1