Liver transplantation for malignant disease

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Recent progress has been made in identifying patients with malignant primary liver tumours who have the best chance of long term survival after orthotopic liver transplantation. Patients with UICC stages I or II hepatocellular carcinoma, the fibrolamellar variant of hepatocellular carcinoma, or epithelioid hepatic hemangioendothelioma are acceptable candidates for othotopic liver transplantation. Carefully selected patients with neuroendocrine tumours metastatic to the liver may also have long-term palliation with liver transplantation. Therapeutic strategies are currently being developed to minimize disease recurrence after liver transplantation for patients with advanced-stage hepatocellular carcinoma confined to the liver or with cholangiocarcinoma. However, published liver tumours remain suboptimal, and significant progress in preventing disease recurrence is required before liver transplantation can be widely applied to most patients with primary malignant liver tumours.

Original languageEnglish (US)
Pages (from-to)285-299
Number of pages15
JournalGastroenterology Clinics of North America
Volume22
Issue number2
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Gastroenterology

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