Liver regeneration

Shennen A. Mao, Jaime M. Glorioso, Scott Nyberg

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

The liver is unique in its ability to regenerate in response to injury. A number of evolutionary safeguards have allowed the liver to continue to perform its complex functions despite significant injury. Increased understanding of the regenerative process has significant benefit in the treatment of liver failure. Furthermore, understanding of liver regeneration may shed light on the development of cancer within the cirrhotic liver. This review provides an overview of the models of study currently used in liver regeneration, the molecular basis of liver regeneration, and the role of liver progenitor cells in regeneration of the liver. Specific focus is placed on clinical applications of current knowledge in liver regeneration, including small-for-size liver transplant. Furthermore, cutting-edge topics in liver regeneration, including in vivo animal models for xenogeneic human hepatocyte expansion and the use of decellularized liver matrices as a 3-dimensional scaffold for liver repopulation, are proposed. Unfortunately, despite 50 years of intense study, many gaps remain in the scientific understanding of liver regeneration.

Original languageEnglish (US)
Pages (from-to)352-362
Number of pages11
JournalTranslational Research
Volume163
Issue number4
DOIs
StatePublished - Jan 1 2014

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Liver Regeneration
Liver
Liver Failure
Wounds and Injuries
Treatment Failure
Hepatocytes
Stem Cells
Animal Models
Transplants
Scaffolds (biology)

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical

Cite this

Liver regeneration. / Mao, Shennen A.; Glorioso, Jaime M.; Nyberg, Scott.

In: Translational Research, Vol. 163, No. 4, 01.01.2014, p. 352-362.

Research output: Contribution to journalReview article

Mao, SA, Glorioso, JM & Nyberg, S 2014, 'Liver regeneration', Translational Research, vol. 163, no. 4, pp. 352-362. https://doi.org/10.1016/j.trsl.2014.01.005
Mao, Shennen A. ; Glorioso, Jaime M. ; Nyberg, Scott. / Liver regeneration. In: Translational Research. 2014 ; Vol. 163, No. 4. pp. 352-362.
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