Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE)

Heng Zhao, Pengfei Song, Duane D. Meixner, Randall R. Kinnick, Matthew R Callstrom, William Sanchez, Matthew W Urban, Armando Manduca, James F Greenleaf, Shigao D Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Shear wave speed can be used to assess tissue elasticity, which is associated with tissue health. Ultrasound shear wave elastography techniques based on measuring the propagation speed of the shear waves induced by acoustic radiation force are becoming promising alternatives to biopsy in liver fibrosis staging. However, shear waves generated by such methods are typically very weak. Therefore, the penetration may become problematic, especially for overweight or obese patients. In this study, we developed a new method called External Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE), in which external vibration from a loudspeaker was used to generate a multi-directional shear wave field. A directional filter was then applied to separate the complex shear wave field into several shear wave fields propagating in different directions. A two-dimensional (2D) shear wave speed map was reconstructed from each individual shear wave field, and a final 2D shear wave speed map was constructed by compounding these individual wave speed maps. The method was validated using two homogeneous phantoms and one multi-purpose phantom. Ten patients undergoing liver Magnetic Resonance Elastography (MRE) were also studied with EVMUSE to compare results between the two methods. Phantom results showed EVMUSE was able to quantify tissue elasticity accurately with good penetration. In vivo EVMUSE results were well correlated with MRE results, indicating the promise of using EVMUSE for liver fibrosis staging.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Pages979-982
Number of pages4
ISBN (Print)9781479970490
DOIs
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Other

Other2014 IEEE International Ultrasonics Symposium, IUS 2014
CountryUnited States
CityChicago
Period9/3/149/6/14

Fingerprint

liver
S waves
elastic properties
vibration
fibrosis
magnetic resonance
penetration
compounding
loudspeakers
sound waves
health
filters
propagation

Keywords

  • Directional filter
  • external vibration
  • liver fibrosis
  • magnetic resonance elastography
  • shear wave elastography
  • shear wave speed

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Zhao, H., Song, P., Meixner, D. D., Kinnick, R. R., Callstrom, M. R., Sanchez, W., ... Chen, S. D. (2014). Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE). In IEEE International Ultrasonics Symposium, IUS (pp. 979-982). [6931850] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0240

Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE). / Zhao, Heng; Song, Pengfei; Meixner, Duane D.; Kinnick, Randall R.; Callstrom, Matthew R; Sanchez, William; Urban, Matthew W; Manduca, Armando; Greenleaf, James F; Chen, Shigao D.

IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society, 2014. p. 979-982 6931850.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhao, H, Song, P, Meixner, DD, Kinnick, RR, Callstrom, MR, Sanchez, W, Urban, MW, Manduca, A, Greenleaf, JF & Chen, SD 2014, Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE). in IEEE International Ultrasonics Symposium, IUS., 6931850, IEEE Computer Society, pp. 979-982, 2014 IEEE International Ultrasonics Symposium, IUS 2014, Chicago, United States, 9/3/14. https://doi.org/10.1109/ULTSYM.2014.0240
Zhao H, Song P, Meixner DD, Kinnick RR, Callstrom MR, Sanchez W et al. Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE). In IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society. 2014. p. 979-982. 6931850 https://doi.org/10.1109/ULTSYM.2014.0240
Zhao, Heng ; Song, Pengfei ; Meixner, Duane D. ; Kinnick, Randall R. ; Callstrom, Matthew R ; Sanchez, William ; Urban, Matthew W ; Manduca, Armando ; Greenleaf, James F ; Chen, Shigao D. / Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE). IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society, 2014. pp. 979-982
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abstract = "Shear wave speed can be used to assess tissue elasticity, which is associated with tissue health. Ultrasound shear wave elastography techniques based on measuring the propagation speed of the shear waves induced by acoustic radiation force are becoming promising alternatives to biopsy in liver fibrosis staging. However, shear waves generated by such methods are typically very weak. Therefore, the penetration may become problematic, especially for overweight or obese patients. In this study, we developed a new method called External Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE), in which external vibration from a loudspeaker was used to generate a multi-directional shear wave field. A directional filter was then applied to separate the complex shear wave field into several shear wave fields propagating in different directions. A two-dimensional (2D) shear wave speed map was reconstructed from each individual shear wave field, and a final 2D shear wave speed map was constructed by compounding these individual wave speed maps. The method was validated using two homogeneous phantoms and one multi-purpose phantom. Ten patients undergoing liver Magnetic Resonance Elastography (MRE) were also studied with EVMUSE to compare results between the two methods. Phantom results showed EVMUSE was able to quantify tissue elasticity accurately with good penetration. In vivo EVMUSE results were well correlated with MRE results, indicating the promise of using EVMUSE for liver fibrosis staging.",
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